| 腹腔镜下Roux-en-Y胃旁路手术对肥胖2型糖尿病患者胰岛素敏感性和单核细胞趋化蛋白影响的研究 |
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| 引用本文： | 闫永鑫,赵鑫,周爱明,陈慧玉,王国凤,徐宁,郑之陈,惠媛.腹腔镜下Roux-en-Y胃旁路手术对肥胖2型糖尿病患者胰岛素敏感性和单核细胞趋化蛋白影响的研究[J].中华糖尿病杂志,2022(2). |
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| 作者姓名： | 闫永鑫 赵鑫 周爱明 陈慧玉 王国凤 徐宁 郑之陈 惠媛 |
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| 作者单位： | 苏州大学附属第一医院普外科;南京医科大学康达学院第一附属医院内分泌科 |
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| 基金项目： | 连云港市卫生科技项目(局1402,201510)。 |
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| 摘 要： | 目的探讨腹腔镜下Roux-en-Y胃旁路手术(LRYGB)对肥胖T2DM患者血清IS和单核细胞趋化蛋白1(MCP-1)的影响。方法选取40例肥胖T2DM患者行LRYGB,ELISA法测定患者术前、术后6个月血清MCP-1水平,应用高胰岛素正葡萄糖钳夹实验评估IS,分析LRYGB对肥胖T2DM患者MCP-1和IS的影响。结果40例肥胖T2DM患者均无术中并发症发生及中转开腹。患者术后6个月HbA1c、FPG、TC、TG及MCP-1水平较术前降低(P<0.05),FIns、葡萄糖代谢率及胰岛素抵抗指数较术前显著改善(P<0.05)。结论LRYGB可改善肥胖T2DM患者IS和MCP-1介导的炎症状态。
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| 关 键 词： | 肥胖 胃旁路手术 糖尿病 2型 胰岛素抵抗指数 单核细胞趋化蛋白1 |
Effect of laparoscopic Roux-en-Y gastric by pass on insulin sensitivity and MCP-1 in obesity patients with type 2 diabetes mellitus |
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| Institution: | (Department of General Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215006,China) |
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| Abstract: | ObjectiveTo explore the effects of laparoscopic Roux-en-Y gastric bypass surgery on insulin sensitivity(IS)and serum monocyte chemotactic protein 1(MCP-1)in obesity patients with type 2 diabetes mellitus(T2 DM)by evaluating the changes of IS and MCP-1 before and after 6 months gastric bypass surgery.this study.MCP-1 was measured by ELISA methods before and after gastric bypass surgery.Hyperinsulinemic euglycemic clamp was applied to evaluate IS.The influence of LRYGB on MCP-1 and IS were analyzed in obesity patients with T2 DM.complications or conversion to open surgery.HbA1c,FPG,TC,TG and MCP-1 levels were lower 6 months after surgery(P<0.05).The fasting insulin,Rd and IR index significantly decreased after surgery(P<0.05).ConclusionLRYGB could improve the IS and MCP-1 mediated inflammatory status in obesity patients with T2 DM. |
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| Keywords: | Obesity Gastric bypass Diabetes mellitus type 2 Insulin resistance index MCP-1 |
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