| 日本血吸虫DNA疫苗pcDNA3/SjSDISP的安全性评价 |
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| 引用本文： | 刘芬,汪世平,蔡胜蓝,余俊龙,彭先楚. 日本血吸虫DNA疫苗pcDNA3/SjSDISP的安全性评价[J]. 中国血吸虫病防治杂志, 2007, 19(1): 21-23 |
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| 作者姓名： | 刘芬 汪世平 蔡胜蓝 余俊龙 彭先楚 |
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| 作者单位： | 1. 中南大学湘雅医学院血吸虫病研究室,长沙,410078;福建中医学院微生物学与寄生虫学教研室
2. 中南大学湘雅医学院血吸虫病研究室,长沙,410078 |
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| 基金项目： | 国家科技攻关项目;国家高技术研究发展计划(863计划);湖南省重大专项基金;湖南省重点学科建设专项 |
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| 摘 要： | 目的评价日本血吸虫DNA疫苗pcDNA3/SjSDISP的安全性。方法同体左右侧自身对比法对3只家兔进行局部肌肉刺激实验,22只豚鼠随机分为4组:A组为无菌生理盐水阴性对照组,B组为牛血清白蛋白阳性对照组,C组为pcDNA3/SjSDISP低剂量组,D组为pcDNA3/SjSDISP高剂量组,进行全身过敏实验。结果日本血吸虫DNA疫苗pcDNA3/SjSDISP对家兔局部肌肉刺激反应轻微,对豚鼠无全身过敏反应。结论日本血吸虫DNA疫苗pcDNA3/SjSDISP在该实验条件下安全。
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| 关 键 词： | 日本血吸虫 DNA疫苗 安全性实验 |
| 文章编号： | 1005-6661(2007)01-0021-03 |
| 修稿时间： | 2006-11-23 |
Security assessment of DNA vaccine pcDNA3/SjSDISP against Schistosoma japonicum |
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| Liu Fen,Wang Shi-ping,Cai Sheng-lan,Yu Jun-long,Peng Xian-chu. Security assessment of DNA vaccine pcDNA3/SjSDISP against Schistosoma japonicum[J]. Chinese journal of schistosomiasis control, 2007, 19(1): 21-23 |
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| Authors: | Liu Fen Wang Shi-ping Cai Sheng-lan Yu Jun-long Peng Xian-chu |
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| Affiliation: | 1 Research Laboratory of Schistosomiasis, College of Xiangya Basic Medicine ,Central South University ,Changsha 410078 ,China;2 Department of Microbiology and Parasitology ,Fujian University of Traditional Chinese Medicine,China |
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| Abstract: | Objective To evaluate the security of DNA vaccine pcDNA3/SjSDISP. Methods Three rabbits were tested for local muscle stimulation with intra-individual left/right self comparison method, and 22 guinea pigs were divided into 4 groups at random(A, physiological saline group; B, bovine serum albumin group; C, low dosage of pcDNA3/SjSDISP; D, high dosage of pcDNA3/SjSDISP) and were tested for systemic anaphylaxis of the vaccine. Results The DNA vaccine pcDNA3/SjSDISP had mild muscle stimulation and no allery effect.Conclusion The DNA vaccine pcDNA3/SjSDISP is safe under the experimental condition. |
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| Keywords: | pcDNA3/SjSDISP |
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