| 巨噬细胞迁移抑制因子调节寄生虫与宿主免疫系统相互作用机制的研究进展 |
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| 引用本文： | 黄琳,马元芬,王灵军,郑明辉,刘晖.巨噬细胞迁移抑制因子调节寄生虫与宿主免疫系统相互作用机制的研究进展[J].中国血吸虫病防治杂志,2019,31(4):446. |
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| 作者姓名： | 黄琳 马元芬 王灵军 郑明辉 刘晖 |
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| 作者单位： | 1 遵义医学院寄生虫学教研室(遵义 563100)；2 黔南民族医学高等专科学校；3 遵义医学院形态学教研室 |
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| 基金项目： | 国家自然科学基金(81560336、81760373）；贵州省教育厅基因检测与治疗特色重点实验室；贵州省遵义市校联合基金[遵义市科合字（2017）08号] |
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| 摘 要： | 巨噬细胞迁移抑制因子（Macrophage migration inhibitory factor，MIF）是一种具有特殊结构的免疫调节细胞因子，参与调控宿主细胞生长、迁移和免疫应答等过程。寄生虫感染宿主后，宿主可产生MIF参与同寄生虫之间的相互作用；同时寄生虫也会分泌虫源性MIF，共同参与调节寄生虫与宿主的相互作用。本文将对寄生虫感染后MIF基因的表达调控、MIF在寄生虫与宿主免疫系统相互作用中的作用，以及MIF介导免疫反应的重要信号通路进行综述。
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| 关 键 词： | 巨噬细胞迁移抑制因子 寄生虫 宿主 免疫反应 相互作用 |
Advances in researches on mechanism of macrophage migration inhibitory factor regulating parasite?host immune interaction |
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| HUANG Lin,MA Yuan-Fen,WANG Ling-Jun,ZHENG Ming-Hui,LIU Hui.Advances in researches on mechanism of macrophage migration inhibitory factor regulating parasite?host immune interaction[J].Chinese Journal of Schistosomiasis Control,2019,31(4):446. |
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| Authors: | HUANG Lin MA Yuan-Fen WANG Ling-Jun ZHENG Ming-Hui LIU Hui |
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| Institution: | 1 Department of Parasitology, Zunyi Medical College, Zunyi 563000, China; 2 Qiannan Medical College for Nationalities, China; 3 Department of Morphology, Zunyi Medical College, China |
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| Abstract: | Macrophage migration inhibitory factor (MIF), a type of pleiotropic immunoregulatory cytokine with a specific structure, participates in the regulation of host cell growth and migration and immune responses. Following parasitic infections, hosts may produce MIF and then participate in the parasite?host interactions. In addition, parasites may secrete parasite?derived MIF, and they jointly participate in parasite?host interactions. This paper reviews the regulation of MIF gene expression following parasitic infections, the role of MIF in parasite?host immune system interactions, and important signaling pathways of MIF?mediated immune responses. |
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| Keywords: | Macrophage migration inhibitory factor (MIF) Parasite Host Immune response Interaction |
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