颈动脉粥样硬化与冠心病关系的研究

目的:研究颈动脉粥样硬化与冠心病的关系。方法:对301例冠状动脉造影的患者作双侧颈动脉超声检查,根据冠脉造影结果分为正常组及冠心病组,冠心病组根据冠状动脉病变支数再分为一支病变组,二支病变组,三支病变组3个亚组。测量颈总动脉后壁内中膜厚度(IMT),斑块厚度,计算斑块积分及粥样斑块发生率。结果:(1)冠心病组IMT,斑块积分及斑块发生率明显高于正常对照组(P<0.01)。(2)随冠脉病变支数增加,斑块积分及IMT增加,亚组比较有显著性差异(P<0.01)。(3)以IMT>0.85mm和(或)出现粥样斑块预测冠心病,特异性75.3％,敏感性84.6％,阳性预测率88.4％。结论:通过颈动脉超声检查可为冠心病的诊断提供依据。

Association of carotid artery atherosclerosis with coronary artery disease

Objective: To investigate the relationship between carotid artery atherosclerosis and coronary artery disease by carotid ultrasound examination. Methods: 301 patients were divided into contrast group and coronary artery diseaes(CAD) group according to the results of coronary angiography. The CAD group was further divided into 1,2,3, stenosed vessel groups. The carotid intima-media wall thickness (IMT), crouse score and plaque incidence were measured. Results: The IMT, crouse score and plaque incidence is significantly higher in CAD groups than in controls. A linear correlation between the IMT, crouse score and the extent of CAD is found. The specificity and sensitivity of using IMT>0. 85mm and/or carotid atherosclerosis plaque with diagnosis CAD is respectively 75. 3% , 84.6% , the positive predictability is 88.4% . Conclusions: Carotid ultrasound examination can provide useful information in the diagnosis of CAD.