高血压前期颈动脉内-中膜厚度及血管内皮舒张功能的变化

目的探索高血压前期外周动脉血管粥样硬化和血管内皮功能的改变。方法检测颈动脉内-中膜厚度（IMT）和肱动脉内皮舒张功能。结果高血压前期组颈动脉分叉、颈总动脉处内-中膜厚度均较正常血压组增厚（P〈0．05）；高血压前期组反应性充血后肱动脉内径变化率（FMD）显著低于正常血压组（P〈0．05）；含服硝酸甘油后肱动脉内径FMD高血压前期组与正常血压组无明显差异（P〉0．05）。结论高血压前期已存在颈动脉内-中膜增厚，血管内皮功能已经受损。

Prehypertension carotid artery the intima-media thickness and vascular endothelial function changes

Objective To explore the prehypertension peripheral artery atherosclerosis and vascular endothelial function changes. Methods The detection of carotid artery the intima-media thickness and brachial artery endothelial function. Results The carotid artery bifurcation, common carotid artery within the Office-in the film thickness thicker than those of normal blood pressure group,significant difference（P 〈0. 05） ;prehypertension group of reactive hyperemia brachial artery diameter after FMD was significantly lower than blood pressure group（P 〈0. 05） ;after sublingual nitroglycerin FMD of brachial artery diameter pre-hypertension and normal blood pressure group was no significant difference（P 〉 0. 05 ）. Conclusion The high blood pressure pre- existing carotid artery - medial thickening,vascular endothelial function has been impaired.