| Nrf2/ARE通路与糖尿病相关动脉粥样硬化 |
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| 引用本文： | 缪莹,万沁.Nrf2/ARE通路与糖尿病相关动脉粥样硬化[J].国际内分泌代谢杂志,2017,37(3). |
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| 作者姓名： | 缪莹 万沁 |
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| 作者单位： | 西南医科大学附属医院内分泌科, 泸州,646000 |
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| 摘 要： | 氧化应激和炎性反应是糖尿病致动脉粥样硬化的两个主要危险因素,Nrf2/ARE通路是体内调控氧化应激的关键通路.激活Nrf2/ARE通路可保护血管内皮细胞、血管平滑肌细胞及胰岛β细胞免受氧化损伤,并可增加胰岛素分泌,改善胰岛素抵抗.Nrf2/ARE通路对糖尿病动脉粥样硬化的防治具有重要意义.
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| 关 键 词： | Nrf2/ARE信号通路 糖尿病 动脉粥样硬化 氧化应激 |
Nrf2/ARE signal pathway and diabetes associated atherosclerosis |
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| Miao Ying,Wan Qin.Nrf2/ARE signal pathway and diabetes associated atherosclerosis[J].International JOurnal of Endocrinology and Metabolism,2017,37(3). |
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| Authors: | Miao Ying Wan Qin |
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| Abstract: | Oxidative stress and inflammation play essential roles in the initiation and progression of diabetes associated atherosclerosis.Nrf2/ARE signal pathway is the key pathway in the regulation of cellular oxidative stress response.The activation of Nrf2/ARE pathway can protect vascular endothelial cells,vascular smooth muscle cells and islet β cells from oxidative stress injury,as well as improve insulin resistance by increasing insulin secretion.Nrf2/ARE pathway plays an important role in the prevent and treatment of diabetes associated atherosclerosis. |
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| Keywords: | Nrf2/ARE signal pathway Diabetes mellitus Atherosclerosis Oxidative stress |
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