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胰高血糖素样肽-1受体激动剂对中枢神经系统的作用
引用本文:傅铮,匡洪宇,郝明.胰高血糖素样肽-1受体激动剂对中枢神经系统的作用[J].国际内分泌代谢杂志,2011,31(4):264-267.
作者姓名:傅铮  匡洪宇  郝明
作者单位:哈尔滨医科大学附属第一医院内分泌科,150001
基金项目:国家自然科学基金资助项目,中国博士后科学基金面上资助项目,省博士后基金项目
摘    要:胰高血糖素样肽-1受体(GLP-1R)激动剂通过GLP-1R刺激胰岛素分泌并改善胰岛细胞的状态,现已成为糖尿病领域研究热点.已证实GLP-1R在中枢神经系统有广泛表达,中枢应用GLP-1R激动剂后其可发挥保护神经细胞、调节食欲、调节认知功能等一系列作用,体现了其在中枢神经系统应用的潜质与价值.

关 键 词:胰高血糖素样肽-1受体  胰高血糖素样肽-1  中枢神经系统  神经病变

Effects of glucagon-like peptide-1 receptor agonists on the central nervous system
FU Zheng,KUANG Hong-yu,HAO Ming.Effects of glucagon-like peptide-1 receptor agonists on the central nervous system[J].International JOurnal of Endocrinology and Metabolism,2011,31(4):264-267.
Authors:FU Zheng  KUANG Hong-yu  HAO Ming
Abstract:Agonist of glucagon-like peptide-I receptor( GLP-1 R)can stimulate insulin secretion and improve the physiological state of islet cells effectively though binding its receptor. It has become a hot topic of diabetes. Studies have shown that GLP-I R was widely expressed in the central nervous system. Agonist of GLP-IR may play some effects in the central nervous system, such as protection of nerve cell, regulation of appetite, influence of cognitive function, etc. These can reflect its potential applications and value.
Keywords:Glucagon like peptide-I receptor  Glucagon like peptide-I  Central nervous system  Neuropathy
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