c-myb在肝细胞癌组织中的表达及临床意义

目的 研究c-myb基因在HCC组织中的表达,探讨其在HCC发生、发展中的作用及临床意义.方法 应用免疫组织化学法检测55例HCC组织、55例癌旁组织、12例肝硬化组织和11例正常肝组织中c-myb蛋白表达情况.结果 癌组织相对于正常的肝组织,癌旁组织相对于肝硬化组织,c-myb蛋白的表达明显增高(P=0.000).结论 提示,c-myb过表达是HCC发病中的早期事件,在HCC的发生、发展中可能起重要作用,检测c-myb的表达具有一定的临床意义.

The expression of c-myb in HCC tissues and clinical significance

Objective To study the expression of c-myb in human hepatocelluar carcinoma tissues,we explored its role in the occurrence and development of HCC and clinical significance.Methods The protein expressions of c-myb were detected in 55 HCC tissues,55 peri-carcinoma tissues,12 hepatic cirrhosis tissues and 11 normal liver tissues by immunohistochemistry.Results The expression of c-myb protein in HCC tissues compared with normal liver tissues,its expression in peri-carcinoma tissues compared with hepatic cirrhosis tissues were significantly higher(P=0.000).Conclusion These suggested that overexpression of c-myb gene might be an early accidence in the pathogenesis of HCC,and might play an important role in the occurrence and development of HCC,detecting the expression of c-myb had clinical significance.