我国丙型肝炎病毒基因1型与非基因1型的临床特征分析

目的初步明确我国HCV基因1型与非基因1型的基本临床特征。方法通过全国多中心、大样本的流行病学调查,经具备国际认证资质的第三方检测机构,采用国际通用的测序法进行病毒基因型分析,并进一步对HCV基因1型与非基因1型的临床特征进行了分析。结果共采集来自全国东西南北中的18个研究中心的764例患者血浆标本,男性384例,女性380例,平均年龄(44.9±14.3)岁,平均病程(7.7±7.3)年。通过临床特征分析发现,基因1型患者年龄分布偏大,病程较长;将横断面调查时患者的ALT水平进行比较,基因1型中有54.9%的患者ALT处于异常,非基因1型中有56.9%的患者ALT处于异常,两者差异无统计学意义(P>0.05);将横断面调查时患者的身体质量指数(BMI)水平进行比较,基因1型中有39.6%的患者BMI异常,非基因1型中有31.6%的患者BMI异常,两者差异无统计学意义(P>0.05);将感染途径分为输血感染与非输血感染,在输血感染患者中,66.1%的输血感染患者为基因1型,在非输血感染患者中,非基因1型占51.1%,两者差异有统计学意义(P<0.05)。结论与非基因1型相比,慢性丙型肝炎基因1型患者年龄分布偏大,病程较长,多为输血感染。

Analysis of clinical characteristics of the infection of HCV genotype 1 and non - genotype 1 in China

Objective To clear preliminary clinical characteristics of the infection of HCV genotype 1 and non-genotype 1 in China.Methods Through a national multi-center,large sample epidemiological survey,certified by an international third-party testing organization qualifications,using the internationally accepted method for sequencing analysis of viral genotype,and further on the clinical characteristics of the infection of HCV genotype 1 and non-genotype 1 were analyzed.Results Plasma samples of 764 patients from 18 research centers of China were collected.384 patients were maleand 380 were female,and the mean age was 44.9 ± 14.3 years,the mean duration was 7.7 ± 7.3 years.By analyzing the clinical features,we found that,in the age distribution and duration of disease,the genotype 1 virus infected patients have a greater age and longer duration than that in non-genotype 1 infected patients.The comparison of the ALT levels in patients with a cross-sectional survey showed that 54.9% with abnormal ALT in genotype 1 patients,and 56.9% in non-genotype 1 patients,There was no significant difference(P>0.05).The comparison of BMI levels in patients showed that abnormal BMI was 39.6% of the patients infected with genotype 1 HCV and 39.6% non-genotype 1.There was no significant difference(P>0.05).We divided the routes of infection into the blood transfusion infection and Non-transfusion routes of infection.In the patients with blood transfusion infection,66.1% were genotype 1,while in the patients with non-infected blood transfusion,non-genotype 1 infection accounted for 51.1%.There was a significant difference(P<0.05).Conclusion Compared with HCV non-genotype 1,HCV genotype 1 infected patients have greater age distribution and longer duration,mostly of them were blood transfusions.