肝脏铁过载的评估及治疗新进展

铁过载为铁在体内过度沉积并导致肝脏、胰腺、心脏、内分泌器官等结构损害和功能障碍的一种病理状态。肝脏为机体储存铁的主要部位,过度铁沉积可诱发肝内炎症及纤维组织增生,后期可发展为肝硬化,甚至肝癌,影响预后。正确的评估及有效的治疗可在一定程度上改善铁过载引起的肝组织损伤,提高患者生存率。

Progress in evaluation and treatment of hepatic iron overload

Iron overload is a metabolic disorder characterized by excessive iron deposition in the liver,pancreas,heart,endocrine organs,etc.,resulting in structural damage and dysfunction. The liver is the primary organ for iron storage,and excessive iron deposition induces liver inflammation and fibrosis,which may progress to cirrhosis and even liver cancer,with a poor prognosis. Accurate evaluation and effective treatment can reduce liver injury caused by iron overload and improve patients＇ survival.