血清皮质醇水平与重型肝炎预后的相关性

目的探讨重型肝炎患者血清皮质醇水平与预后的关系,为临床判断预后及探讨治疗提供理论依据。方法对临床诊断的重型肝炎患者进行血清皮质醇、TNFα含量检测;比较重型肝炎、急性肝炎和慢性肝炎患者血清皮质醇水平的差异以及重型肝炎患者中死亡组和存活组的差异;检测血清皮质醇含量与TNFα含量的相关性。结果重型肝炎患者血清皮质醇水平明显低于急、慢性肝炎患者,尤以死亡组患者更为明显;血清皮质醇水平与TNFα含量呈显著负相关。结论重型肝炎患者存在肾上腺皮质功能不全,且与患者预后密切相关。

Relationship between sera hydrocortisone level and the prognosis of fulminant hepatitis

Objective To investigate the relationship between different genotypes of hepatitis B virus（HBV） and the expression of HBeAg and the severity of liver diseases.Methods The HBV genotypes were determined by multiple-primer PCR amplification and the HBV DNA levels were detected by fluorescent quantitative PCR assay.Results In 120 HBV infected cases,84 cases（70%） were genotype C,31 cases（25.8%） were genotype B and 5 cases（4.2%） were mixed genotype BC;genotypes A,D,E,F were not detected.More patients were HBeAg-positive than were HBeAg-negative in Genotype C（P0.05）.There was no significant difference between the HBeAg negative and HBeAg positive in genotyoe B.Conclusion This study suggests that genotype B and C are predominant genotype in Xuzhou area.The HBeAg positive expression is predominant in genotype C.Compare to the patients with genotype B,more severe inflammation was observed in patients with genotype C.