| 替比夫定与恩替卡韦治疗慢加急性肝衰竭的疗效分析 |
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| 引用本文： | 郑玉山,孙凤兰,刘现红.替比夫定与恩替卡韦治疗慢加急性肝衰竭的疗效分析[J].临床肝胆病杂志,2011,27(6):641-642,646. |
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| 作者姓名： | 郑玉山 孙凤兰 刘现红 |
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| 作者单位： | 济宁市传染病医院肝病科,山东济宁,272031 |
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| 摘 要： | 目的观察替比夫定和恩替卡韦治疗慢加急性肝衰竭临床疗效。方法选择57例乙型肝炎慢加急性肝衰竭患者,替比夫定组28例,使用替比夫定600 mg/d;恩替卡韦组29例,使用恩替卡韦0.5 mg/d。观察指标为肝功能、凝血酶原时间（PT）、HBV DNA,分别于治疗后2、4、6、8、12周取值,因为生存率的问题,肝功能、PT只取2、4、6周进行对比。结果替比夫定组和恩替卡韦组病死率分别为21.43%、48.28%,差异有统计学意义;两组HBV DNA阴转率及时限上相比均不具有统计学意义。两组治疗后PT、胆碱酯酶、TBil、血清白蛋白（Alb）随着治疗时间的延长,均改善,但在治疗后第2、4、6周相同时间点时比较,差异均有统计学意义（P〈0.01）,替比夫定组改善较恩替卡韦组改善提前。结论替比夫定治疗慢加急性肝衰竭,能有效降低病死率
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| 关 键 词： | 肝功能衰竭 替比夫定 恩替卡韦 |
Comparative study on the therapeutic effects of telbivudine and entecavir on acute-on-chronic liver failure |
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| ZHENG Yu-shan,SUN Feng-lan,LIU Xian-hong.Comparative study on the therapeutic effects of telbivudine and entecavir on acute-on-chronic liver failure[J].Chinese Journal of Clinical Hepatology,2011,27(6):641-642,646. |
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| Authors: | ZHENG Yu-shan SUN Feng-lan LIU Xian-hong |
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| Institution: | ZHENG Yu-shan,SUN Feng-lan,LIU Xian-hong.(Department of Liver Disease,Hospital for Infectious Diseases of Jining,Jining,Shandong 272031,China) |
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| Abstract: | Objective To observe the clinical effects of telbivudine and entecavir on acute-on-chronic liver failure.Methods Fifty-seven patients with acute-on-chronic liver failure infected with viral hepatitis B were chosen and divide into 2 groups: the Telbivudine group(of 28 cases) treated with 600 mg Telbivudine /day and the Entecavir group(of 29 cases)treated with 0.5 mg Entecavir /day.The indicators for observation were liver function,prothrombin time(PT) and HBV DNA.The results of observation were taken at the ... |
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| Keywords: | liver failure telbivudine entecavir |
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