| 自身免疫性肝炎发病机制研究进展 |
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| 引用本文： | 王倩怡,贾继东.自身免疫性肝炎发病机制研究进展[J].临床肝胆病杂志,2011,27(6):572-576. |
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| 作者姓名： | 王倩怡 贾继东 |
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| 作者单位： | 首都医科大学附属北京友谊医院肝病中心,北京,100050 |
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| 摘 要： | 自身免疫性肝炎的病因及发病机制尚未完全阐明,目前多数学者认为具有遗传易感性的个体在多种诱因作用下,自身免疫耐受机制遭到破坏,机体逐渐不能耐受自身抗原,从而导致出现疾病特异性的自身抗体并在肝脏内出现免疫细胞浸润。深入研究发病机制,有助于在诊断、治疗及预防上取得根本性突破。本文就自身免疫性肝炎发病机制的研究进展作一综述
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| 关 键 词： | 肝炎 自身免疫性 |
Advances in the pathogenesis of autoimmune hepatitis |
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| WANG Qian-yi,JIA Ji-dong.Advances in the pathogenesis of autoimmune hepatitis[J].Chinese Journal of Clinical Hepatology,2011,27(6):572-576. |
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| Authors: | WANG Qian-yi JIA Ji-dong |
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| Institution: | WANG Qian-yi,JIA Ji-dong.(Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China) |
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| Abstract: | The etiology and mechanisms of autoimmune hepatitis(AIH) are poorly understood.The general notion is that AIH is the final result of loss of immune tolerance triggered by environmental factors to autoantigens derived from hepatocytes in genetically predisposing subjects.Better understanding of the pathogenesis of AIH at the molecular level are of paramount importance in developing new diagnostic and therapeutic strategies.This article summarized the recent advances in the pathogenesis of AIH. |
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| Keywords: | hepatitis autoimmune |
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