| 小鼠病毒性心肌炎与心肌细胞凋亡的关系 |
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| 引用本文： | 钱素娟,李晖.小鼠病毒性心肌炎与心肌细胞凋亡的关系[J].中国地方病学杂志,1997,16(3):132-134. |
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| 作者姓名： | 钱素娟 李晖 |
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| 作者单位： | 哈医大克山病研究所，哈医大微生物教研室，哈医大电镜室 |
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| 摘 要： | 实验通过给５周龄ＢＡＬＢ／Ｃ小鼠腹腔接种Ｃｏｘｓａｃｋｉｅ Ｂ３ｍ病毒（ＣＶＢ３ｍ），诱发小鼠急性病毒性心肌炎（ＶＭＣ），感染病毒９天后处死小鼠，利用光镜、电镜及原位末端标记法对心肌组织进行检测，结果显示：ＶＭＣ检出率为９３．３３％，心肌细胞凋亡阳性率为８０．００％，凋亡细胞多分布于心内膜下、心外膜下心肌组织，血管内皮细胞和坏死病灶周围，提示细胞凋亡可能是小鼠ＶＭＣ的发病机制之一。
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| 关 键 词： | 心肌炎 细胞凋亡 病毒性心肌炎 |
Relationship between viral myocarditis and apoptosis of myocardium in mice |
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| Qian Sujuan,Li Hui,Zhou Lingwang,et al Keshan Disease Institute,Harbin Medical University,Harbin.Relationship between viral myocarditis and apoptosis of myocardium in mice[J].Chinese Jouranl of Endemiology,1997,16(3):132-134. |
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| Authors: | Qian Sujuan Li Hui Zhou Lingwang Keshan Disease Institute Harbin Medical University Harbin |
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| Institution: | Qian Sujuan,Li Hui,Zhou Lingwang,et al Keshan Disease Institute,Harbin Medical University,Harbin,150086 |
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| Abstract: | Viral myocarditis(VMC)may be induced by coxsackie B 3m Virus (CVB 3m ).The CVB 3m was inoculated into abdominal cavity of BALB/C mice aged 5 weeks in this experiment,then the mice were killed in 9 days.The hearts of the mice were examined using TDT/dUTP Nick end Labeling (T/UNEL)of fragmented DNA and electronic microscopy.The Results showed that detectable rate of VMC was 93.33% and positive rate of apoptosis of myocardium was 80.00%.These results indicated that apoptosis may be one of the mechanisms causing myocyte damage in myocarditis of mice. |
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| Keywords: | Virus Myocarditis\ Apoptosis |
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