| 冠状病毒的氨基肽酶N受体的研究进展 |
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| 引用本文： | 陈杰,黄小波,张雨迪,卿盈,李亚青,文心田,曹三杰,文翼平,伍锐.冠状病毒的氨基肽酶N受体的研究进展[J].中国人兽共患病杂志,2016,32(1):89-94. |
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| 作者姓名： | 陈杰 黄小波 张雨迪 卿盈 李亚青 文心田 曹三杰 文翼平 伍锐 |
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| 作者单位： | 四川农业大学动物医学院,猪病研究中心/动物传染病与基因芯片室,成都 611130 |
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| 摘 要： | 氨基肽酶N(Aminopeptidase N, APN)是一种锌离子依赖性膜结合II型的金属跨膜糖蛋白,其广泛存在于人和哺乳动物的多种组织细胞中。APN是多种冠状病毒的黏附性受体,参与冠状病毒的粘附与侵袭,与病毒感染密切相关。本文对多种冠状病毒(HCoV-229E、FCoV、CCoV、TGEV、PEDV)的APN受体的结构、功能、抑制剂等研究进展进行了总结,重点介绍了其作为人和猪冠状病毒功能受体的进展。本文为深入研究和应用冠状病毒APN受体提供参考。
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| 关 键 词： | 氨基肽酶N 冠状病毒 受体 |
| 收稿时间： | 2015-05-11 |
Review of aminopeptidase N as the receptor of coronavirus |
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| CHEN Jie,HUANG Xiao-bo,ZHANG Yu-di,QING Ying,LI Ya-qing,WEN Xin-tian,CAO San-jie,WEN Yi-ping,WU Rui.Review of aminopeptidase N as the receptor of coronavirus[J].Chinese Journal of Zoonoses,2016,32(1):89-94. |
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| Authors: | CHEN Jie HUANG Xiao-bo ZHANG Yu-di QING Ying LI Ya-qing WEN Xin-tian CAO San-jie WEN Yi-ping WU Rui |
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| Institution: | 1. Research Center of Swine Disease /Laboratory of Animal Infectious Disease and Microarray,College of Veterinary Medicine, Sichuan Agricultural University , Chengdu 611130, China |
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| Abstract: | Aminopeptidase N(APN), a type II transmembrane glycoprotein that belongs to zinic-dependent membrane-bound metallopretease family, exists in many tissues of human and mammals as the binding-receptor of coronavirus. Participating in the coronavirus adhesion and invasion, aminopeptidase N is closely related to the coronavirus infection. In this essay, there is an overview of structure, function and inhibitors of aminopeptidase N that as functional receptor of HCoV-229E, FCoV, CCoV, TGEV, PEDV. This paper mainly introduces the progress of aminopeptidase N as functional receptors of human and swine coronavirus, so as to provide a reference to further research and application of APN receptor. |
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| Keywords: | aminopeptidase N coronavirus receptor |
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