老年退行性心脏瓣膜病与多器官疾病发生的调查分析

目的：分析老年退行性心脏瓣膜病（SDHVD）与多器官疾病的发生状况。方法老年人3896例，男2884例，女1012例，年龄60～103（78±13）岁。所有研究对象均进行心脏彩超、体检、相关辅助检查，并对多器官疾病进行分析。结果3896例患者中，SDHVD1225例（31.4%），无SDHVD2671例（68.6%），SDHVD组与对照组多器官疾病的发病率分别为高血压病49.3%vs 28.4%，冠心病38.5%vs23.8%，心力衰竭36.2%vs 17.3%，肺心病6.3%vs 3.1%，脑卒中21.6%vs 9.6%，肾功能不全6.9%vs 3.2%，胃食管反流病21.3%vs 10.3%，两组比较差异均有统计学意义（P＜0.05），而糖尿病为11.2%vs 12.1%，两组比较差异无统计学意义（P＞0.05）。结论 SDHVD组多器官疾病显著增高，可能由于SDHVD心脏重构改变，血流动力学异常，促发了多器官疾病的发生。

Senile degenerative heart valvular disease and multiple organ diseases: a clinical study

ObjectiveTo investigate senile degenerative heart valvular diseases （SDHVD） and multiple organ diseases. MethodsA multi-center study was carried out in somesanatoriums for retiredveterancadresand their couples from October 2008 to June 2014. There were 3896 elderly patients recruited （all with full medical records and undergoing overall physical examination every year）, including 2884 males and1012females,with ageof（78±13） years （ranging from60 to 103 years）. Clinical data of their echocardiography, physical examination, and auxiliary examination were collected and analyzed for multiple organ diseases.Results Among the 3896 elderly patients, there were 1225 having SDHVD （31.4%）. The incidences of multiple organ diseases in the SDHVD group and non-SDHVD groupwere as follows respectively： hypertension 49.3%vs 28.4%, coronary heart disease 38.5%vs23.8%, heart failure 36.2%vs 17.3%, pulmonary heart disease 6.3%vs 3.1%, stroke 21.6%vs 9.6%, renal insufficiency 6.9%vs 3.2%,gastroesophageal reflux disease 21.3%vs 10.3%, and diabetes mellitus 11.2%vs 12.1%. Significant differences were found in all above incidences except for that of diabetes mellitus between the 2 groups （P〈0.05）.Conclusion Multiple organ diseasesare more common in the elderly suffering from SDHVD. It might be due tothatSDHVDinducescardiac remodelingandabnormalhemodynamics, and thus triggersthe occurrence and development of multiple organ diseases.