| 迈之灵对下肢慢性静脉功能不全患者微循环的改善效果 |
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| 引用本文： | 王威,乌兰,聂皓,廖鹏志,李方达,刘端,赵瑜,张望德,卞策,党永康,郑月宏.迈之灵对下肢慢性静脉功能不全患者微循环的改善效果[J].中华老年多器官疾病杂志,2018,17(7):486-490. |
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| 作者姓名： | 王威 乌兰 聂皓 廖鹏志 李方达 刘端 赵瑜 张望德 卞策 党永康 郑月宏 |
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| 作者单位： | 中国医学科学院北京协和医院血管外科;赤峰市医院血管外科;重庆医科大学附属第一医院血管外科;首都医科大学附属北京朝阳医院血管外科;解放军火箭军总医院心脏大血管科 |
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| 基金项目： | 国家自然科学基金面上项目(81470586；81770481)；北京市自然科学基金面上项目(7172171)；中国医学科学院医学与健康科技创新工程(2017-12M-1-008) |
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| 摘 要： | 目的分析迈之灵对下肢慢性静脉功能不全(CVI)患者微循环指标的改善情况。方法入选2016年3月至2017年8月中国医学科学院北京协和医院和赤峰市医院血管外科门诊就诊的CVI患者40例,根据治疗方式分为迈之灵组23例和对照组17例。迈之灵组给予迈之灵及弹力袜治疗,对照组仅采用弹力袜治疗,疗程为4周。观察主要疗效指标流行病学和经济研究(VEINES)/生活质量(QOL)/症状(Sym)问卷评分、经皮氧分压(TcPO_2)、皮肤温度]、次要疗效指标(温控血流及阻断后反应性充血)和不良反应,并对疗效和安全性进行评估。采用SPSS 20.0统计软件进行数据处理及分析。组间比较采用t检验、Mann-Whitney U检验或χ~2检验。结果完成病例36例,迈之灵组22例,对照组14例。迈之灵组治疗前相比治疗后VEINES-QOL(69.3±13.5)vs(76.7±11.9)分]、VEINES-Sym(31.9±7.9)vs(36.0±7.4)分]、TcPO_2(45.2±22.3)vs(56.3±16.5)mm Hg]、皮肤温度32.6(31.5,33.9)℃vs 31.8(31.0,32.9)℃]和温控血流(151.4±123.0)%vs(418.0±179.5)%]差异均有统计学意义(P0.05)。对照组治疗前相比治疗后VEINES-QOL(64.0±16.1)vs(69.0±16.7)分]、VEINES-Sym(29.3±7.7)vs(32.6±7.9)分]和TcPO_2(39.6±16.8)vs(51.4±9.9)mm Hg]差异有统计学意义(P0.05)。迈之灵组相比对照组治疗前后的温控血流差值(266.6±170.1)%vs(-110.1±160.5)%]差异有统计学意义(P0.05)。结论迈之灵在一定程度上可改善CVI患者生活质量及临床症状,其疗效可能与其对下肢微循环的改善作用有关。微循环指标中TcPO_2、皮肤温度、温控血流可能在一定程度上反映CVI患者下肢微循环的变化。CVI的发病机制可能与下肢微循环改变有密切关联。
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| 关 键 词： | 下肢静脉功能不全 微循环 迈之灵 |
| 收稿时间： | 2018/1/15 0:00:00 |
| 修稿时间： | 2018/2/23 0:00:00 |
Effects of Aescuven forte on microcirculation for the treatment of chronic venous insufficiency |
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| WANG Wei,WU Lan,NIE Hao,LIAO Peng-Zhi,LI Fang-D,LIU Duan,ZHAO Yu,ZHANG Wang-De,BIAN Ce,DANG Yong-Kang and ZHENG Yue-Hong.Effects of Aescuven forte on microcirculation for the treatment of chronic venous insufficiency[J].Chinrse journal of Multiple Organ Diseases in the Elderly,2018,17(7):486-490. |
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| Authors: | WANG Wei WU Lan NIE Hao LIAO Peng-Zhi LI Fang-D LIU Duan ZHAO Yu ZHANG Wang-De BIAN Ce DANG Yong-Kang and ZHENG Yue-Hong |
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| Institution: | Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,Department of Vascular Surgery, Chifeng Municipal Hospital, Chifeng 024000,China,Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,Department of Vascular Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China,Department of Vascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100043, China,Department of Heart Vascular Surgery, the General Hospital of PLA Rocket Force, Beijing 100088, China,Department of Vascular Surgery, Chifeng Municipal Hospital, Chifeng 024000,China and Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China |
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| Abstract: | |
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| Keywords: | chronic venous insufficiency microcirculation aescuven forte |
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