慢性阻塞性肺疾病患者夜间缺氧与肺功能损减的关系

目的分析慢性阻塞性肺疾病（COPD）患者肺功能受损与夜间低氧缺氧的关系。方法对排除了睡眠呼吸暂停低通气综合征的160例稳定期COPD患者进行夜间脉搏氧饱和度监测和肺功能检测。进行年龄及体质量指数匹配后，按COPD肺功能分级将患者分为3组：轻度缺氧、中度缺氧、重度缺氧组。比较各组间夜间缺氧的严重程度。结果各组间在夜间平均血氧饱和度血氧饱和度低于90％时间占总睡眠时间百分比、夜间平均脉搏、每小时脉搏上升6次的次数等方面差异有显著性（P〈0．01）。而且肺活量占预计值百分比、1秒钟用力呼气容积占预计值百分比、残气容积、残气容积与肺总量比值差异亦有显著性（P〈0．05）。结论COPD患者夜问缺氧的严重程度与肺功能受损的程度明显相关，这可能会影响患者的心血管系统。

Association of nocturnal hypoxemia with impairment of lung function in patients with chronic obstructive pulmonary disease

Objective To investigate the relationship between nocturnal hypoxemia and impairment of pulmonary function in patients with chronic obstructive pulmonary disease（COPD）. Methods We excluded patients with sleep apnea hypopnea syndrome.One hundred and sixty patients with stable COPD were recruited. The subjects underwent home pulse oximetry and lung function testing and were divided into 3 groups： mild, moderate and severe nocturnal hypoxemia groups according to COPD severity. The three groups were matched for age and body mass index. The degree of nocturnal desaturation was compared among the three groups. Results There were significant differences in mean oxygen saturation, the percentage of time spent at oxygen saturation below 90, mean nocturnal pulse rate, BPM6 among the three groups （P〈0.01）. Also, there were differences among three groups in regard to the major parameters of lung function, such as percentage of forced vital capacity, percentage of forced expiratory volume in 1 second, residual volume and residual volume/total lung capacity ratio. Conclusion Lung function impairment is associated with nocturnal hypoxemia in patients with COPD, which may have a negative influence on cardiovascular system.