脓毒血症发病机制研究进展

脓毒血症是指感染和创伤等诱发的剧烈全身性炎症反应,并引起组织器官继发性损伤的临床症候群。在临床上,因脓毒血症所导致的脓毒症性休克是重症监护患者最常见的死亡原因。随着抗生素的广泛应用,大肠埃希菌等条件致病菌感染所致脓毒血症已呈现上升趋势。固有免疫通过模式识别方式识别脂多糖等病原体成分,进而活化免疫细胞和释放细胞因子以排除病原体。但此过程中释放的大量炎症性细胞因子、免疫细胞的凋亡亦是引发毒脓血症和脓毒症性休克的重要机制。

Progress of research on the mechanisms of sepsis

Pyemia is a syndrome with multiple organ or tissue damage caused by systematic inflammatory reactions resulting from infection and trauma.Clinically,septic shock caused by sepsis is a frequent cause of death for patients in intensive care.With the extensive use of antibiotics,the rate of sepsis caused by opportunistic pathogenic bacteria such as E.coli has increased.Innate immunity eliminates pathogens through the recognition of pathogen components such as lipopolysaccharides through pattern recognition.Thi...