胎盘生长因子在非小细胞肺癌胸腔积液中的表达及其对临床疗效的影响

目的 探讨胎盘生长因子(PlGF)在非小细胞肺癌(NSCLC)并发胸腔积液患者中的表达及其对临床疗效的影响.方法 回顾性分析比较44例NSCLC并发恶性胸腔积液患者血清和胸腔积液中PlGF的表达水平;并与患者的临床疗效做相关分析.结果 NSCLC患者血清中PlGF的表达水平为(545.05±26.35) ng/L,显著高于健康对照者(478.62±17.82) ng/L].而在NSCLC胸腔积液中PlGF的水平为(1 094.61±176.48) ng/L,显著高于漏出性胸腔积液(100.81±43.97) ng/L;但与炎症性良性胸腔积液中PlGF水平(933.54±216.29) ng/L]比较,差异无统计学意义.患者治疗后,疗效判定分别为完全缓解13例,部分缓解16例,无效15例;3个疗效组中PlGF表达水平依次升高,完全缓解＜部分缓解＜无效,差异有统计学意义(F=24.62,P＜0.01),而治疗效果则依次递减.结论 PlGF在NSCLC并发恶性胸腔积液患者血清和胸腔积液中呈高水平表达,且与患者的临床疗效呈负相关.PlGF作为促血管生成因子,在NSCLC的发病中可能通过刺激肿瘤血管的生长和渗透性而促进胸腔积液的生成.

Expression of placental growth factor in pleural effusion of non-small cell lung cancer patients and its impact on clinical effects

Objective To explore the placental growth factor (PlGF) expression in the serum and malignant pleural effusion (MPE) of non-small cell lung cancer (NSCLC) patients and its impact on the clinical effects.Methods PlGF level in the serum and MPE from 44 NSCLC patients was analyzed and compared,and the relationship of PlGF level and clinical effects was assessed.Results PlGF level in the serum of NSCLC patients was (545.05 ± 26.35) ng/L,which was significantly higher than that of healthy individuals (478.62± 17.82) ng/L].The level of PlGF in MPE was (1 094.61 ± 176.48) ng/L,which was significantly higher than that in transudative pleural effusion (100.81 ± 43.97) ng/L].However,there was no significant difference in PlGF expression between exudative pleural effusion (933.54 ± 216.29) ng/L] and MPE.After treatment,there were 15 cases in invalid group,16 cases in partial response group,13 cases in complete response group respectively.PlGF level in three curative effect groups had statistical significance difference,and the higher level of PlGF with the worse clinical efficacy.Conclusions PlGF level is high in MPE of NSCLC patients and there is a negative correlation between PlGF level and clinic effects.As angiogenesis factor,PlGF may play an important role in the onset of NSCLC with MPE by stimulating the growth of tumor blood vessels and inflammatory exudation.