阻塞性睡眠呼吸暂停低通气综合征患者血清Chemerin、Apelin水平与胰岛素抵抗关系研究

目的探讨男性OSAHS患者血清Chemerin、Apelin水平与胰岛素抵抗的关系。方法选择0sAHS患者65例和健康对照组28例，分别采用酶联免疫吸附法测定所有研究对象血清Chemerin、Apelin水平，应用稳态模型评估胰岛素抵抗指数（HOMA-IR）。结果与对照组比较，OSAHS患者血清Chemerin、Apelin水平及HOMAIR均高于对照组（P值均〈0．05）。血清Chemerin和Apelin-12水平与AHI呈正相关（r=0．541和0．506，P〈0．01），与LSaO2和MsaO2均呈负相关（r=-0．451，-0．401和-0．428，-0．385，P值均〈0．01）。血清Chemerin和Apelin-12水平与HOMA-1R呈正相关（r=0．438和0．375，P〈0．05），血清Chemerin与血清Apelin-12水平两者呈正相关（r值=0．511，P〈0．01）。患者HOMA-IR变化与AHI、LSaO2、血清Chemerin和Apelin-12水平呈线性回归关系。结论OSAHS患者血清Chemerin、Apelin水平与胰岛素密切相关，同时与患者严重程度和低氧相关．

Correlation between serum chemerin and apelin levels and insulin resistance in patients with obstructive sleep apnea hypopnea syndrome

Objective To analysis the correlation between serum chemerin and apelin levels and insulin resistance in male patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods Sixty-five OSAHS patients （OSAHS group） and 28 healthy voluntrers （control group） were recruited in the study. The states of insulin resistance were evaluated by Homeostasis model assessment. Serum chemerin and apelin levels were measured by ELISA method. Results Compared to the control group,the levels of serum chemerin （0.62±0.10） ng/L vs （0.29±0.03） ng/L and apelin （26.37±8.61） μg/L vs （17.69±4.33） μg/L were significantly higher in patients with OSAHS（ P 〈0.01）. The homeostasis model assessment insulin resistance（HOMA-IR） was higher in OSAHS group （ P〈0.05）. The level of serum chemerin and apelin levels were positive correlation to AHI and HOMA-IR （ r = 0. 541,0. 506 and 0. 438,0. 375） ,which were negatively correlated to the lowest SaO2 and MSaOe （ r =-0. 451, -0. 401 and 0. 428, -0. 385） ,all P 〈0.01. The level of serum chemerin and apelin levels was positive correlated （r=0.511, P 〈0.01）. The HOMA-IR were in multiple linear regression with AHI,LSaO2,serum chemerin and apelin levels. Conclusions The levels of serum ehemerin and apelin were increased and insulin resistance existed in OSAHS patients,and they are correlated to AHI and hypoxia during sleep.