慢性阻塞性肺疾病患者纤毛摆动时间的研究

目的 探讨慢性阻塞性肺疾病(COPD)患者纤毛摆动时间和肺功能的关系,及黏液纤毛清除功能(MCC)在COPD发病中的作用.方法 手术切除的支气管组织30例,分为COPD组、吸烟组及对照组,每组10例,光镜下观察活性纤毛细胞的百分率及纤毛摆动时间,并计数各个时间点的摆动纤毛细胞的百分率,收集临床资料包括吸烟指数、体质量指...

Cilia beat time of the patients with chronic obstructive pulmonary disease

Objective To study the relationship between cilia beat time and pulmonary function in bronchial epithelia of smokers with normal pulmonary function and patients with chronic obstructive pulmonary disease(COPD). Methods We got tissue samples from surgical resection, the patients were allocated into group NS (nonsmokers with normal lung function), group S ( smokers with normal lung function) ,group COPD( smokers with stable COPD), with 10 patients in each group. The percentage of active ciliated cells and cilia beat time was counted in the light microscope, and the percentage of swing ciliated cells was also counted. The clinical datas including body mass index,smoking index,and pulmonary active ciliated cells in group COPD,group S and group NS was (51. 22±7. 73) % vs (54. 66±8. 18) %vs (68. 53± 9. 11) % , P ＜0. 05] , the percentage of group COPD and group S was significantly lower than group NS( P ＜ 0. 05). The cilia beat time was (538. 45 ± 27. 17) min vs (540. 68 ± 25. 61) min vs (688. 52±30. 56) min] ,respectively. The time of group COPD and group S was significantly shorter than group NS( P ＜0. 05). But there was no significant difference between group COPD and group S( P ＞index( r = -0. 5763,- 0. 5213, P＜0.05).The cilia beat time of group COPD was positively associated with FEV1 %pred( r = 0. 6831, P＜0. 05). There was a positive correlation between the cilia beat time and body mass index( r =0. 6831, P ＜0. 05). Conclusions There existed ciliary dysfunction in COPD patients and smokers. Smoking might play a role in the ciliary dysfunction and it is vital in the pathogenesis of COPD. The more severe COPD was,the worse the ciliary dysfunction may be.