| 脑缺血后血管生成的分子机制 |
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| 引用本文： | 张健,曾进胜.脑缺血后血管生成的分子机制[J].国际脑血管病杂志,2010,18(2). |
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| 作者姓名： | 张健 曾进胜 |
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| 作者单位： | 中山大学附届第一医院神经内科,广州,510080 |
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| 摘 要： | 血管生成是脑缺血后自身修复和重塑的重要机制,在促进脑缺血后局部血液循环、保护神经元、改善神经功能等方面起着重要作用,血管生成素、生长因子、基质金属蛋白酶、组织型激肽释放酶、抗血管生成蛋白等多种分子和信号转导通路参与了该过程的调控.文章综述了这些分子和信号转导通路在脑缺血后血管生成中的作用.
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| 关 键 词： | 脑缺血 新生血管化 生理性 细胞分化 细胞运动 血管生成蛋白质类 内皮细胞 卒中 |
Molecular mechanisms of angiogenesis after cerebral ischemia |
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| ZHANG Jian,ZENG Jin-sheng.Molecular mechanisms of angiogenesis after cerebral ischemia[J].International Journal of Cerebrovascular Diseases,2010,18(2). |
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| Authors: | ZHANG Jian ZENG Jin-sheng |
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| Abstract: | Angiogenesis is an important self-repair and remodeling mechanism after cerebral ischemia. It plays pivotal roles in promoting local blood circulation, protecting neurons and improving neurological function after cerebral ischemia. A variety of molecules and signal transduction pathways involved in the regulation of the process, including angiogenin, growth factors, matrix metalloproteinases, tissue kallikrein and anti-angiogenic proteins. This article reviews the roles of these molecules and signal transduction pathways in angiogenesis after cerebral ischemia. |
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| Keywords: | Brain ischemia Neovascularization physiologic Cell differentiation Cell movement Angiogenic proteins Endothelial cells Stroke |
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