| 高迁移率族蛋白 B1与缺血性卒中 |
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| 引用本文： | 曹翔,徐运.高迁移率族蛋白 B1与缺血性卒中[J].国际脑血管病杂志,2016(3):263-267. |
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| 作者姓名： | 曹翔 徐运 |
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| 作者单位： | 南京大学医学院附属鼓楼医院神经科 |
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| 基金项目： | 国家自然科学基金(81230026) Fund program:National Natural Science Foundation of China (81230026) |
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| 摘 要： | 高迁移率族蛋白 B1(high mobility group protein box 1, HMGB1)是一种典型的非组蛋白,在细胞核内具有多种功能。近年来的研究表明,HMGB1可释放到细胞外发挥广泛的细胞学效应。缺血性卒中是发病率和致残率最高的疾病之一。越来越多的证据表明,HMGB1在缺血性卒中的发生和发展过程中起到多种重要作用。文章就 HMGB1在缺血性卒中中的作用进行了综述。
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| 关 键 词： | 卒中 脑缺血 HMGB1 蛋白 炎症 |
High-mobility group protein B1 and ischemic stroke |
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| Abstract: | High mobility group protein box 1 (HMGB1) is a typical nonhistone chromosomal protein. It has many celular functions in nucleus. Studies in recent years have showed that HMGB1 can be released to the outside of cels to exert a wide range of cytological effects. Ischemic stroke is one of the diseases with the highest morbidity and disability. More and more evidence has shown that HMGB1 plays a variety of important roles in the occurrence and development process of ischemic stroke. This article reviews the roles of HMGB1 in ischemic stroke. |
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| Keywords: | Stroke Brain Ischemic HMGB1 Protein Inflammation |
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