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Frailty index to predict all-cause mortality in Thai community-dwelling older population: A result from a National Health Examination Survey cohort
Institution:1. Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundarció Sant Joan de Déu, Dr Antoni Pujades, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain;2. Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5. Pabellón 11, 28029 Madrid, Spain;3. Pharmacy Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain;4. Department of Psychiatry, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario la Princesa, Madrid, Spain;5. Department of Health Statistics and Information Systems, World Health Organization, Geneva, Switzerland;6. Department of Medical Sociology, Jagiellonian University Medical College, Krakow, Poland;7. National Institute for Health and Welfare, Helsinki, Finland;8. Neurology, Public Health and Disability Unit, Neurological Institute \"Carlo Besta\" Foundation IRCCS (Istituto di ricovero e cura a carattere scientifico), Milan, Italy;9. Visiting Fellow at Institute for Health Metrics and Evaluation, University of Washington, 2301 Fifth Avenue, mSuite 600, Seattle, WA 98121, USA;1. School of Medicine, The University of Queensland, Brisbane, QLD, Australia;2. Centre for Research in Geriatric Medicine, The University of Queensland, Brisbane, QLD, Australia;3. QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia;4. Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Abstract:BackgroundFrailty is a clinical state of increased vulnerability from aging-associated decline. We aimed to determine if a Thai Frailty Index predicted all-cause mortality in community-dwelling older Thais when accounting for age, gender and socioeconomic status.MethodsData of 8195 subjects aged 60 years and over from the Fourth Thai National Health Examination Survey were used to create the Thai Frailty Index by calculating the ratio of accumulated deficits using a cut-off point of 0.25 to define frailty. The associations were explored using Cox proportional hazard models.ResultsThe mean age of participants was 69.2 years (SD 6.8). The prevalence of frailty was 22.1%. The Thai Frailty Index significantly predicted mortality (hazard ratio = 2.34, 95% CI 2.10–2.61, p < 0.001). The association between frailty and mortality was stronger in males (hazard ratio = 2.71, 95% CI 2.33–3.16). Higher wealth status had a protective effect among non-frail older adults but not among frail ones.ConclusionsIn community-dwelling older Thai adults, the Thai Frailty Index demonstrated a high prevalence of frailty and predicted mortality. Frail older Thai adults did not earn the protective effect of reducing mortality with higher socioeconomic status. Maintaining health rather than accumulating wealth may be better for a longer healthier life for older people in middle income countries.
Keywords:Frailty  National health examination survey  Thai frailty index  Mortality  Socioeconomic  Middle income countries
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