Vascular development in endometriosis |
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Authors: | PG Groothuis AW Nap E Winterhager R Grümmer |
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Institution: | (1) Research Institute GROW, Department of Obstetrics and Gynaecology, University Hospital Maastricht, Maastricht, The Netherlands;(2) Institute of Anatomy, University Hospital Duisburg-Essen, Essen, Germany |
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Abstract: | Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes
pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social
and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and
persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis
in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.
Correspondence to: Patrick G. Groothuis, Research Institute GROW, Department of Obstetrics and Gynecology, Academisch Ziekenhuis Maastricht,
Peter Debyelaan 25, 6229 HX Maastricht, The Netherlands. Tel:␣+31-43-3876625; Fax: +31-43-3876613; E-mail: patrick.groothuis@
path.unimaas.nl |
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Keywords: | angiogenesis chronic inflammation endometriosis endometrium invasion migration peritoneum vasculogenesis |
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