| 生理剂量睾酮通过雄激素受体改善小鼠行为学能力的研究 |
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| 引用本文： | 洪雷,吴赛珠,郑华,周忠江,邢晓雯,张莉.生理剂量睾酮通过雄激素受体改善小鼠行为学能力的研究[J].中国老年学杂志,2010,30(9). |
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| 作者姓名： | 洪雷 吴赛珠 郑华 周忠江 邢晓雯 张莉 |
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| 作者单位： | 南方医科大学附属南方医院心内科,广东,广州,510515 |
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| 基金项目： | 国家"973"项目子项目 |
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| 摘 要： | 目的 探讨生理剂量的雄激素对小鼠行为学的影响及其机制.方法 29只4 w龄的C57BL/6J雄鼠分为正常组、去势组、去势+丙酸睾酮(TP)组,16只4 w龄的不表达有活性雄激素受体(AR)的睾丸女性化(tfm)雄鼠分为tfm组、tfm+TP组,造模3个月后对各组小鼠进行自主活动能力、避暗穿梭实验和水迷宫实验测定,最后由Nissl染色观测海马区的细胞形态学变化.结果 各项行为学检测及大脑海马区Nissl染色结果均一致,正常组、去势+TP组小鼠的各项指标结果皆显著优于去势组、tfm组和tfm+TP组小鼠,而去势组、tfm组和tfm+TP组之间未见统计学差异.结论 雄激素通过AR途径维持大脑海马区的正常形态来改善小鼠的自主活动能力、学习记忆能力.
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| 关 键 词： | 丙酸睾酮 雄激素受体 行为学 睾丸女性化小鼠 |
Physiological doses of testosterone improve the ability of mouse behavior via androgen receptor |
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| HONG Lei,WU Sai-Zhu,ZHENG Hua,et al.Physiological doses of testosterone improve the ability of mouse behavior via androgen receptor[J].Chinese Journal of Gerontology,2010,30(9). |
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| Authors: | HONG Lei WU Sai-Zhu ZHENG Hua |
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| Institution: | HONG Lei,WU Sai-Zhu,ZHENG Hua,et alDepartment of Cardiovascular,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China |
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| Abstract: | Objective To investigate the effects of physiological doses of testosterone on the ability of mouse behavior. Methods 29 4-week-old C57BL / 6J male mice were divided into normal,castrated,castrated + testosterone propionate (T) groups randomly,16 testicular feminizated (tfm) male mice which expressed non-functional androgen receptor(AR) were divided into tfm,tfm + T groups randomly. After 3 months of treatment,the behaviors of mice were measured by spontaneous motors,step-through and water-maze tests. The s... |
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| Keywords: | Testosterone propionate Adrogen receptor Behavior Testicular feminizated mouse |
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