冠心病相关环状RNA调控机制及治疗的研究进展

环状RNA（circRNA）是一种非编码RNA，具有靶向调节小RNA（miRNA）或信使RNA（mRNA）的功能，参与动脉粥样硬化、免疫反应、血管新生、细胞凋亡、细胞增殖、细胞衰老和细胞自噬等多种冠心病（CHD）病理机制。基于circRNA构建的circRNA/miRNA/mRNA交互网络，有助于系统地、动态地反映CHD的发生发展。同时，通过药物干预或人工过表达/敲低circRNA的异常表达，以及circRNA序列编辑等方法，circRNA为今后CHD的靶向和精准治疗提供了新靶点和新策略。尽管如此，目前有关CHD的circRNA调控机制和治疗研究仍处于初级阶段，明确CHD circRNA生物标志物和治疗靶点仍任重而道远。

Research progress in regulatory mechanism and treatment of circular RNA for coronary heart disease

Circular RNA (circRNA) is a non-coding RNA that commonly targets the regulation of small RNA (miRNA) or messenger RNA (mRNA), instead of direct translation of proteins. It participates in several pathological processes of coronary heart disease (CHD) involving atherosclerosis, immune response, angiogenesis, apoptosis, cell proliferation, cellular senescence and autophagy. Moreover, the circRNA/miRNA/mRNA interaction network based on circRNA helps to systematically and dynamically understand the occurrence and development of CHD. Through drug intervention, artificial overexpression/knockdown of circRNA expression, or sequence editing, circRNA also provides some new target and strategy for the precise treatment of CHD. However, current studies about mechanisms and treatment of circRNA for CHD are still in their infancy, and more clear circRNA biomarkers and therapeutic targets still need to be confirmed by further in-depth researches in the future.