| 环状RNA:心肌缺血/再灌注损伤干预研究新进展 |
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| 引用本文： | 胡梦弦,何贵新,吴成强,秦伟彬,郑国坤,冯雨菲,肖婷,玉黎燕,申永艳.环状RNA:心肌缺血/再灌注损伤干预研究新进展[J].心脏杂志,2020,32(4):408-412. |
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| 作者姓名： | 胡梦弦 何贵新 吴成强 秦伟彬 郑国坤 冯雨菲 肖婷 玉黎燕 申永艳 |
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| 作者单位： | 1.西医内科学教研室，广西 南宁 530299 广西中医药大学 |
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| 基金项目： | 国家自然科学基金地区基金项目资助（81960861，81460712）；广西科学重点研发计划项目资助（桂科AB19110006） |
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| 摘 要： | 环状RNA（circular RNA,circRNA）是一类新型的内源性非编码RNA，其结构是以其3'端和5'端间以共价键形式相连接而形成的一种circRNA。其因结构稳定、分布广泛、组织表达具有特异性和时序性而备受科学工作者的关注。研究表明circRNA在心肌缺血/再灌注损伤中充当着重要角色，可能作为缺血/再灌注损伤潜在的治疗靶点和生物标志物。本文就circRNA形成的途径、功能和在心肌缺血/再灌注损伤中的作用机制以及中医相关方面进行综述。
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| 关 键 词： | 环状RNA 心血管疾病 mirRNA海绵 细胞凋亡 生物标志物 |
| 收稿时间： | 2020-03-28 |
Circular RNA: new progress in intervention of myocardial ischemia-reperfusion injury |
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| Institution: | 1.Department of Internal Medicine of Western Medicine Guangxi University of Traditional Chinese Medicine, Nanning 530299, Guangxi, China2.Department of Cardiology, First Affiliated Hospital, Guangxi University of Traditional Chinese Medicine, Nanning 530023, Guangxi, China |
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| Abstract: | Circular RNA (circRNA) is a new type of endogenous non-coding RNA. Its structure is a circular shape formed by the covalent bond between its 3' and 5' ends RNA. Because of its stable structure, wide distribution and specific and sequential expression of tissues, it has attracted much attention of scientists. Studies have shown that circular RNA plays an important role in myocardial cell ischemia-reperfusion injury and it may be a potential therapeutic target and biomarker for I/R. This article reviews the circRNA formation pathway, functions and its role and mechanism in ischemia-reperfusion injury and the related aspects of traditional Chinese medicine. |
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