失重对血管内皮细胞的影响及其机制研究进展

失重可以导致血管内皮细胞的结构和功能发生变化，自噬和内质网应激都是细胞为维持自身稳态和应对环境变化而产生的应激性反应，研究表明，模拟失重可以使血管内皮细胞增殖水平提高，细胞凋亡受到抑制，细胞迁移能力增强，这些生理变化都伴随着血管内皮细胞自噬活性的增强，失重导致的内质网应激发生时细胞的凋亡增加，提示自噬和内质网应激可能在失重致血管内皮细胞功能变化中起调节作用。本文综述了自噬和内质网应激在失重致血管内皮细胞功能改变中的作用。

Research progress on effects of weightlessness on vascular ndothelial cell and its mechanism

Weightlessness can lead to change the structure and function of endothelial cells, autophagy and endoplasmic reticulum stress are cells in order to maintain its steady state and response to environmental changes and the stress response, study shows that the simulated weightlessness can improve the standards of vascular endothelial cell proliferation, apoptosis is restrained, cell migration, These physiological changes were accompanied by enhanced autophagy activity of vascular endothelial cells, and increased apoptosis in er stress induced by weightlessness, suggesting that autophagy and ER stress may play a regulatory role in the functional changes of vascular endothelial cells induced by weightlessness. This paper reviews the role of autophagy and endoplasmic reticulum stress in the functional changes of vascular endothelial cells induced by weightlessness.