莫沙必利联合二甲硅油散在慢性便秘患者结肠镜检查肠道准备中的应用

目的观察胃肠动力药莫沙必利联合二甲硅油散在慢性便秘患者行电子结肠镜检查前肠道准备过程中的应用效果。 方法选取徐州医科大学附属淮安医院拟行电子纤维结肠镜检查的慢性便秘患者300例，采用随机数字表法分为A组(复方聚乙二醇电解质散联合二甲硅油散)150例、B组(在A组的基础上联合莫沙必利口服)150例。采用Boston肠道量表进行肠道准备质量的评分、肠道气泡量表用于评估肠道内气泡的数量，并记录患者肠道准备时间，进镜时间及退镜时间、不良反应发生情况以及肠道疾病检出情况。 结果AB组2组实际完成肠镜检查过程分别为143例和146例，B组BBPS大于6分的比例明显高于A组(χ²＝5.141，P<0.05)；B组肠道泡沫量评中I、Ⅱ级所占比例明显高于A组(χ²＝5.851，P<0.05)。且肠道准备所用时间、不良反应发生率及肠道病变检出率，B组也明显优于A组，差异有统计学意义(P<0.05)。 结论莫沙必利联合二甲硅油散作为肠道准备用药可以明显提高慢性便秘患者肠道清洁质量的同时显著减少肠腔内气泡的产生，也能减少肠道准备所用时间、降低不良反应发生率、提高肠道病变的检出率。

Application of mosapride combined with dimethicone in bowel preparation before colonoscopy in patients with chronic constipation

ObjectiveTo observe the effect of gastrointestinal motility drug mosapride combined with dimethicone in the process of bowel preparation before electronic colonoscopy in patients with chronic constipation. MethodsA total of 300 patients with chronic constipation who underwent electron fiber colonoscopy in Huai′an Hospital Affiliated to Xuzhou Medical University were enrolled in the study.All the patients were divided into group A(compound polyethylene glycol electrolyte combined with dimethicone, n=150)group and group B(oral mosapride on the basis of group A, n=150)using random number table method.The Boston Bowel Preparation Scale(BBPS)was used to score the quality of the bowel preparation, the intestinal bubble scale was used to estimate the number of bubbles in the intestine, and the patient′s bowel preparation time, time to enter the mirror and time to retreat, adverse reactions, and intestinal diseases detection situation were recorded. ResultsThe number of patients who completed the colonoscopy was 143 in group A and 146 in group B. The proportion of BBPS greater than 6 in group B was significantly higher than that in group A(χ²=5.141, P<0.05). The proportion of gradeⅠandⅡin the evaluation of intestinal foam in group B was significantly higher than that in group A(χ²=5.851, P<0.05). The time of bowel preparation, the incidence of adverse reactions and the detection of intestinal lesions in group B were also significantly better than those in group A(P<0.05). ConclusionAs a bowel preparation drug, mosapride combined with dimethicone can significantly improve the intestinal cleansing quality of patients with chronic constipation and significantly reduce the generation of bubbles in the intestinal cavity, and also shorten the bowel preparation time, reduce the incidence of adverse reactions, and improve the detection rate of intestinal lesions.