抗菌药物不同应用方式对心肌梗死患者介入治疗后感染的预防效果比较

目的探讨抗菌药物不同应用方式在心肌梗死患者介入治疗后感染中的预防效果。方法以深圳市第三人民医院2010年12月至2018年12月接受介入治疗的200例急性心肌梗死患者作为研究对象,根据抗菌药物的应用方法分为A组、B组、C组和D组。A组(50例)术前和术后均使用抗菌药物;B组(50例)术前使用抗菌药物,术后不使用抗菌药物;C组(50例)术前不使用抗菌药物,术后使用抗菌药物;D组(50例)术前和术后均未使用抗菌药物,比较四组介入治疗后感染发生率,记录住院时间。结果A组、B组、C组和D组介入治疗后感染发生率为4%、6%、6%和18%,A组、B组和C组感染发生率组间比较差异无统计学意义(P>0.05),A组、B组、C组感染发生率均明显低于D组,组间比较差异有统计学意义(P<0.05)。A组、B组、C组和D组的住院时间分别为(8.7±1.2)d、(8.5±1.4)d、(8.4±1.1)d和(14.3±1.2)d,A组、B组、C组的平均住院时间均明显短于D组,组间比较差异有统计学意义(P<0.05)。结论介入手术前后使用抗菌药物可有效预防急性心肌梗死术后感染,临床上应合理应用。

Comparison of the preventive effect of different antibiotics on infections in patients with myocardial infarction after interventional therapy

Objective To explore the preventive effect of different application methods of antibiotics on infection after interventional therapy in patients with myocardial infarction after interventional therapy.Methods 200 patients with acute myocardial infarction who underwent interventional therapy in our hospital were divided into group A,group B,group C and group D according to the application method of antibiotics.Group A(50 cases)used antibiotics preoperatively and postoperatively,group B(50 cases)used antibiotics before operation,group C(50 cases)did not use antibiotics before operation and antibiotics were used after operation,and group D(50 cases)did not use antibiotics before and after interventional therapy.The incidence of infection after interventional therapy was compared among the four groups,and hospital stay were recorded.Results The incidence of infection was 4%,6%,6%and 18%in group A,group B,group C and group D after interventional therapy.There was no significant difference in the incidence of infection between group A,group B,and group C.The incidence of infection in group A,group B and group C was significantly lower than that in group D(P<0.05).The average hospitalization time of group A,group B,group C and group D was(8.7+1.2)d,(8.5+1.4)d,(8.4+1.1)D and(14.3+1.2)D.The average hospital length of stay of group A,group B and group C was significantly shorter than that of group D.The difference between groups was statistically significant(P<0.05).Conclusion The use of antibiotics before and after interventional surgery can effectively prevent postoperative infection of acute myocardial infarction,and should be reasonably applied in clinic.