健脾益肝方对非酒精性脂肪性肝病患者脂肪分布及脂代谢的影响

目的:探讨健脾益肝方对非酒精性脂肪性肝病(NAFLD)患者脂肪分布及脂代谢的影响。方法:将80例NAFLD患者随机分为对照组和治疗组各40例。两组患者均在多学科联合管理下给予个体化的饮食、运动等生活方式指导,治疗组患者在此基础上加用健脾益肝方,疗程均为3个月。通过生物电阻抗技术测量患者治疗前后脂肪质量及分布,定期监测肝肾功能、血脂指标。比较两组患者肥胖、脂肪分布、血脂指标变化。结果:治疗组患者有效率为97.5%,明显高于对照组的82.5%,差异有统计学意义(P<0.05);治疗组患者BMI、BFP、WHR、TC、TG及LDL-C水平明显低于对照组,差异有统计学意义(均P<0.05);治疗组患者躯干及内脏脂肪沉积改善明显优于对照组,差异有统计学意义(均P<0.05)。结论:生活方式干预联合健脾益肝方治疗NAFLD患者能显著改善患者的肥胖及脂代谢紊乱,并且与躯干和内脏脂肪质量的下降密切相关。

Effect of Jianpi Yigan recipe on fat distribution and lipid metabolism in patients with non-alcoholic fatty liver disease

Objective:To observe the effect of Jianpi Yigan recipe on fat distribution and lipid metabolism in patients with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 80 NAFLD patients was randomly divided into a control group and a treatment group with 40 cases each.Both groups were given individualized diet,exercise,and other lifestyle guidance under multidisciplinary joint management,the treatment group was treated with Jianpi Yigan decoction on the basis of the control group,the course of treatment was three months.Use bioelectrical impedance technology to measure the patient’s fat mass and distribution before and after treatment,regularly monitor liver and kidney function and blood lipid indexes.Comparing the two groups of patients’obesity indicators,fat distribution indicators,blood lipid index changes.Results:The effective rate of the treatment group was 97.5%,which was significantly higher than that of the control group,the difference was marked significant(P<0.05);After treatment,the levels of BMI,BFP,WHR,TC,TG,and LDL-C in the treatment group were obviously decreased comparing with the control group,and the difference were marked significant(P<0.05);The improvement of the trunk and visceral fat deposition in the treatment group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Lifestyle intervention combined with Jianpi Yigan Recipe in the treatment of NAFLD patients can significantly improve obesity and lipid metabolism disorders in patients and is closely related to the decline of the trunk and visceral fat mass.