| 替米沙坦联合苯那普利对糖尿病肾病患者的肾保护作用 |
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| 引用本文： | 童学敏,徐斌,张秀敏,李继文.替米沙坦联合苯那普利对糖尿病肾病患者的肾保护作用[J].实用心脑肺血管病杂志,2009,17(4):274-275. |
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| 作者姓名： | 童学敏 徐斌 张秀敏 李继文 |
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| 作者单位： | 上海市浦东新区川沙社区卫生服务中心,201205 |
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| 摘 要： | 目的探讨替米沙坦联合苯那普利治疗糖尿病肾病（DN）的临床疗效及安全性，为临床合理选择用药提供依据。方法80例2型糖尿病肾病患者随机分为替米沙坦组、联合治疗组各40例，两组患者均给予常规降血糖治疗，包括严格控制饮食、适当体育运动、降血脂、口服降血糖药物，部分患者注射胰岛素制剂，使HbA1c在6．5g／L以下。治疗期间均停用其他降压药物。替米沙坦组用替米沙坦片60mg／d；联合治疗组用替米沙坦片30mg／d，苯那普利片10mg／d，疗程均为3月。观察治疗前后各组血肌酐（Scr）、糖化血红蛋白（HBA1c）、尿中总蛋白（TP）的变化。结果两组患者治疗前HbA1c、TP、肌酐（SCr）水平间差异无统计学意义（P〉0．05）。疗程中未发现严重不良反应。治疗后两组HbA1c间差异无统计学意义（P〉0．05）。治疗后两组患者尿TP、血Scr间差异均有统计学意义（P〈0．05）。结论替米沙坦联合苯那普利治疗糖尿病肾病更有效、更合理，并无明显不良反应。
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| 关 键 词： | 替米沙坦 苯那普利 糖尿病肾病 |
The Protective Effects of Telmisartan and Benazepri on Patients with Diabetic Nephropathy |
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| Institution: | TONG Xue - min,XU Bin, ZHANG Xiu - min,et al.( Chuansha Hospital, Shanghai 201205, China) |
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| Abstract: | Objective To study the effects of telmisartan and benazepri on patients with diabetic nephropathy （DN）, so as to provide the rationality of clinical medication. Methods In this study 80 patients with DN were randomly divided into three groups： group A received telmisartan, group B telmisartan combine benazepri for 3 months. Scr, HbA1c and Total urinary albumin excretion serumwere observe. Results There were significant differences （ P 〈 0. 05 ） among these two groups protein after treatment. There are lower levels of Ser, HbA1c and total urinary albumin in combine group than the other group. Conclusion Losartan combined with eaptopril was more effective and rational in treating patients with early DN without side effec. |
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| Keywords: | Telmisartan Benazepri Diabetic nephropathy |
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