铜绿假单胞菌注射液胸腔灌注治疗恶性胸腔积液的临床分析

目的观察铜绿假单胞菌注射液胸腔灌注治疗恶性胸腔积液的临床疗效及毒副反应。方法将70例晚期非小细胞肺癌伴恶性胸腔积液患者随机分为观察组和对照组,每组各35例。对照组在常规辅助治疗的基础上予以洛铂胸腔灌注治疗,观察组在对照组的基础上辅以铜绿假单胞菌注射液胸腔灌注,观察比较两组患者治疗后的临床疗效及毒副反应。结果治疗疗程结束后,多数患者胸腔积液情况得到了有效的控制,两组治疗的总有效率分别为77.1%和48.6%(P0.05)。两组患者治疗过程中的毒副反应主要以发热、胃肠道反应及骨髓抑制为主,两组比较差异无统计学意义(P0.05)。结论洛铂联合铜绿假单胞菌注射液比单独洛铂胸腔灌注治疗恶性胸腔积的疗效显著,毒副反应相当,可推荐临床应用。

Clinical analysis of pleural perfusion pseudomonas aeruginosa injection in the treatment of malignant pleural effusion

Objective To observe the clinical effect and side effect of pseudomonas aeruginosa injection in the treatment of NSCLC with malignant pleural effusion. Methods 70 NSCLC patients with malignant pleural effu-sion were randomly divided into two groups, 35 cases in each group. In addition to conventional therapy, the control group was treated with lobaplatin through intrathoracic infusion, and the observation group was additionally treated with pseudomonas aeruginosa injection on the base of the control group. The clinical efficacy and side effect were compared between the two groups. Results After treatment, pleural effusion in majority patients was effectively con-trolled, and the total effective rate was 77. 1% in the observation group and 48. 6% in the control group (P<0. 05). The side effect in the two groups mainly included fever, gastrointestinal reaction, and bone marrow suppression ( P>0. 05). Conclusion Lobaplatin combined with pseudomonas aeruginosa injection has better curative effect than lobaplatin alone dose in the treatment of NSCLC with malignant pleural effusion, with similar side effect.