哮喘患儿血清维生素D水平改变与炎症因子和肺功能的相关性研究 |
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引用本文: | 黄静,项珊,张晓霞,余启超.哮喘患儿血清维生素D水平改变与炎症因子和肺功能的相关性研究[J].临床肺科杂志,2016(9):1611-1614. |
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作者姓名: | 黄静 项珊 张晓霞 余启超 |
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作者单位: | 黄石市中医院儿科, 湖北 黄石,435000 |
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摘 要: | 目的探讨哮喘患儿血清维生素D水平改变与炎症因子和肺功能的相关性。方法收集80例哮喘患儿和40例健康儿童,比较两组肺功能情况和血清维生素D水平差异。结果哮喘患儿血清25(OH)D3、TGFβ水平降低,INFγ、TNFα和IL-6增高与对照组比较有显著性差异(P均0.05);哮喘组患儿血清维生素D水平与TGFβ呈正相关,与IL-1β和IL-6呈负相关(P均0.05)。结论哮喘患儿血清维生素D水平明显较低,与炎症因子具有一定的相关性。
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关 键 词: | 哮喘 血清维生素D水平 肺功能 促炎因子 抗炎因子 |
Correlation analysis of serum total vitamin D and inflammation factors in asthma children |
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Abstract: | Objective To evaluate the correlation analysis of serum total vitamin D and inflammation factors in asthma children .Methods 80 asthma children and 40 healthy controls were enrolled in this study .Pulmonary function test and serum vitamin D level were compared and analyzed in the two groups .Results The levels of TGFβand vitamin D in the asthma group were significantly lower than those in the control group (P<0.05).The levels of INF-γ, TNF-αand IL-6 in the asthma group were significantly higher in the control group (P<0.05).Pearson cor-relation analysis showed that the levels of serum vitamin D in the asthma group were positively associated with TGF -β(P<0.05) and negatively associated with IL-1βand IL-6 (P<0.05).Conclusion The levels of serum vitamin D in asthma children are lower , which is related with inflammation factors . |
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Keywords: | asthma serum vitamin D level pulmonary function pro-inflammatory factor anti-inflammato-ry factor |
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