雾化吸入布地奈德混悬液治疗AECOPD疗效分析

目的观察雾化吸入布地奈德混悬液在慢性阻塞性肺疾病急性加重期（AECOPD）的疗效。方法将46例患者分为雾化吸入激素组23例,全身应用激素组23例,两组患者均给予常规吸氧、抗炎、扩张支气管、止咳、袪痰治疗。观察治疗10d后患者的呼吸功能,血气分析指标及不良反应发生率。结果两组患者治疗前各指标比较无明显差异,治疗后肺功能及血气分析指标均有显著改善,但雾化吸入激素组不良反应发生率明显低于全身应用激素组,两者相比差异显著（P〈0.05）,有统计学意义。结论布地奈德混悬液治疗AECOPD疗效可靠,安全,副作用少,临床值得推广。

Analysis of inhaling budesonide in the treatment of acute exacerbations of chronic obstructive pulmonary disease

Objective To observe the curative effect when inhaling budesonide to cure acute exacerbations of chronic obstructive pulmonary disease（AECOPD）.Methods Forty-six patients hospitalized with AECOPD were divided into two groups（inhalation group of 23 cases,and Ⅳ injection group of 23 cases）.The patients in the control group were treated with standard therapy only,the patients in the inhalation group attached to inhaling budesonide suspension with oxygen,and those in the Ⅳ injection group were treated with Ⅳ injection prednisolone.All the patients underwent pulmonary function test,arterial blood gas analysis at entry and ten days after the therapy.Results There were significant improvement of all pulmonary function and arterial blood gas relevant parameters in both groups but there were more adverse reactions in the Ⅳ injection group than in the inhalation group after therapy（P0.05）.Conclusions Budesonide inhalation suspension of 2.0 mg twice daily with oxygen is an effective and safe method in the treatment of AECOPD patients.