| e抗原阴性慢性乙型肝炎临床病理相关性分析 |
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| 引用本文： | 何卫平,胡瑾华,王琳,陈婧,王慧芬.e抗原阴性慢性乙型肝炎临床病理相关性分析[J].肝脏,2008,13(1):11-13. |
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| 作者姓名： | 何卫平 胡瑾华 王琳 陈婧 王慧芬 |
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| 作者单位： | 1. 北京解放军第三○二医院肝衰竭治疗研究中心,100039
2. 中华医学会 |
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| 摘 要： | 目的了解HBeAg阴性慢性乙型肝炎临床和病理表现的相互关系。方法对154例HBeAg阴性慢性乙型肝炎患者进行血生化、病毒标志物及病毒定量检测，与肝组织病理进行相关性分析。结果病理诊断中、重度患者数量多于临床分度数量（80例对37例），白蛋白／球蛋白和凝血酶原活动度（PTA）对重度肝炎诊断有一定的临床价值，HBVDNA水平和抗-HBe是否阳性与肝脏损害程度无关，血清透明质酸水平与肝纤维化程度相关（χ^2=6．9376，P=0．039）。结论HBeAg阴性慢性乙型肝炎患者应尽可能行肝脏病理检查以明确诊断，并指导治疗。
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| 关 键 词： | 肝炎E抗原 乙型 慢性乙型肝炎 透明质酸 病理学 |
| 收稿时间： | 2007-10-15 |
| 修稿时间： | 2007年10月15 |
Clinical pathology character analysis of HBeAg-negative chronic hepatitis B |
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| HE Wei-ping,HU Jin-hua,WANG Lin,CHEN Jing,WANG Hui-fen.Clinical pathology character analysis of HBeAg-negative chronic hepatitis B[J].Chinese Hepatology,2008,13(1):11-13. |
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| Authors: | HE Wei-ping HU Jin-hua WANG Lin CHEN Jing WANG Hui-fen |
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| Institution: | HE Wei-ping HU Jin-hua WANG Lin CHEN Jing WANG Hui-fen.The Liver Failure Therapy , Research Centre,302 Hospital of PLA,Beijing 100039,China. |
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| Abstract: | Objective To analyse the clinical and pathologic characters of HBeAg-negative chronic hepatitis B pa- tients.Methods 154 HBeAg-negative chronic hepatitis B patients were selected,liver function test,virus marker and vi- rus loading were observed,correlation analysis was performed with pathological grading.Results The patient's number diagnosed by pathology from moderate to severe hepatitis is higher than that diagnosed by clinical manifestation (80 vs 37).It is valuable clinically to diagnose severe hepatit... |
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| Keywords: | HBeAg Chronic hepatitis B Hyaluronic acid Pathology |
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