| 缬沙坦对非勺型高血压患者血压昼夜节律的影响 |
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| 引用本文： | 李亚雄,曾文双,邓远飞.缬沙坦对非勺型高血压患者血压昼夜节律的影响[J].岭南心血管病杂志,2011,17(6):454-455. |
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| 作者姓名： | 李亚雄 曾文双 邓远飞 |
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| 作者单位： | 北京大学深圳医院VIP病房,广东深圳,518036 |
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| 摘 要： | 目的观察缬沙坦对非勺型高血压患者血压昼夜节律的影响。方法选择经24h动态血压监测且诊断为非勺型2级高血压的患者60例为研究对象，将其按电脑数字表法随机均分为治疗组30例：上午7：00和晚上7：00各服缬沙坦80mg；对照组30例：上午7：00服缬沙坦160mg，两组用药8周后复测24h动态血压。比较两组血压昼夜节律的变化。结果两组治疗后24h、白昼、夜间收缩压及舒张压均较治疗前显著下降，差异有统计学意义（P〈0．05）。治疗组的夜间收缩压、舒张压及白昼、夜间血压负荷较对照组显著下降，差异有统计学意义（P〈0．05）。治疗组血压昼夜节律改变有效率明显高于对照组，差异有统计学意义（收缩压：73．33％抵46．67％，P〈0．05；舒张压：76．67％眠43．33％，P〈0．01）。结论应用缬沙坦治疗非勺型高血压，可以很好地控制2级高血压，并改变血压昼夜节律，早晚两次服用，效果更好。
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| 关 键 词： | 高血压 缬沙坦 动态血压监测 |
Effect of valsartan on blood pressure diurnal rhythm in patients with non-dipping hypertension |
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| LI Ya-xiong,ZENG Wen-shuang,DENG Yuan-fei.Effect of valsartan on blood pressure diurnal rhythm in patients with non-dipping hypertension[J].South China Journal of Cardiovascular Diseases,2011,17(6):454-455. |
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| Authors: | LI Ya-xiong ZENG Wen-shuang DENG Yuan-fei |
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| Institution: | LI Ya-xiong,ZENG Wen-shuang,DENG Yuan-fei(Department of VIP,Peking University Shenzhen Hospital,Shenzhen Guangdong 518036,China) |
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| Abstract: | Objectives To observe the effect of valsartan with defferent dose and time on blood pressure diurnal rhythm in patients with non-dipper hypertension.Methods A total of 60 patients with miderate essential hypertension(EH) were randomly divided into two groups: treatment group(n=30) were treated with 80 mg at 7 AM valsartan and 80 mg valsartan at 7 PM;and control group(n=30) were treated with 160 mg valsartan at 7 AM.The changes of 24 h blood pressure and blood pressure diurnal rhythm before treatment and 8 w... |
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| Keywords: | hypertension valsartan ambulatory blood pressure monitoring |
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