阿魏酸钠对兔急性心肌梗死再灌注后无复流的影响

目的探讨阿魏酸钠（sodium ferulate，SF）对兔急性心肌梗死（acute myocardial infarction，AMI）再灌注后无复流的影响。方法随机将24只成熟雄性新西兰大白兔分为假手术组、对照组、SF组3组，每组8只。分别建立AMI缺血再灌注模型，于缺血前5min、结扎后4h，再灌注后2h取静脉血。应用放射免疫法测定血清和心肌组织内皮素-1（endothelin-1，ET-1）浓度。采用酶联免疫吸附法（ELISA）测定血清白细胞介素-6（interleukin-6,IL-6）。应用硫黄素染色评估无复流面积。结果①对照组和SF组AMI后4h、再灌注后2h血清ET-1浓度高于假手术组，差异有统计学意义（P均〈0．01）；与AMI前比较，对照组及SF组AMI后4h、再灌注后2h的血清ET-1浓度均显著升高（P均〈0．01）；SF组AMI后4h、再灌注后2h的血清ET-1浓度均显著低于对照组（P均〈0．01）。②对照组和SF组复流区和无复流区心肌组织中ET-1浓度均显著高于假手术组心肌组织（P均〈0．01）。SF组复流区心肌组织中的ET-1浓度显著低于对照组（P均〈0．01）。③对照组和SF组AMI后4h、再灌注后2h血清IL-6浓度显著高于假手术组（P均〈0．01）；与AMI前比较，对照组及SF组AMI后4h、再灌注后2h的血清IL-6浓度均显著升高（P均〈0．01）；SF组血清IL-6浓度显著低于对照组（P均〈0．05）。④病理染色分析示，SF组无复流区心肌范围为57．54％±8．36％，与对照组83．91％±5．35％相比显著降低（P〈0．01）。结论SF能有效保护兔内皮功能，抑制炎症反应．防治AMI再灌注后无复流。

Effect of sodium ferulate on no-reflow in a rabbit model of acute myocardial infarction and reperfusion

Objectives To evaluate the effects of sodium ferulate(SF) on no-reflow phenomenon in a rabbit model of acute myocardial infarction(AMI) and reperfusion.Methods Twenty-four mature male rabbits were randomly divided into sham-operated group,control group,sodium ferulate group(25 mg /kg,once 30 min before coronary artery ligation) with 8 in each group.The later 2 groups were subjected to 4 h of left anterior descending occlusion followed by 2 h of reperfusion.The concentrations of ET-1 in serum,normal,infracte...