急性冠脉综合征患者冠状动脉介入治疗围术期可溶性CXC趋化因子配体16的表达规律

目的 探讨可溶性CXC趋化因子配体16 （soluble CXCL16,sol-CXCL16）在急性冠状动脉（冠脉）综合征患者经皮冠状动脉介入（percutaneous coronary intervention,PCI）治疗围术期中的表达规律及临床意义.方法 将96例成功施行PCI治疗的急性冠脉综合征患者分为常规治疗组和强化他汀治疗组,分别于PCI治疗前、PCI治疗后1d、术后2周以及术后4周测定血清sol-CXCL16和高敏C-反应蛋白（high-sensitivity C-reactive protein,hs-CRP）的浓度.结果 所有患者PCI治疗后1d血清hs-CRP浓度和sol-CXCL16浓度均较PCI治疗前有明显的升高,差异有统计学意义（P＜0.05）.PCI治疗后1d常规治疗组中血清sol-CXCL16浓度升高较强化他汀治疗组更为明显,差异有统计学意义（P＜0.05）.治疗2周后,强化他汀治疗组血清sol-CXCL16浓度较常规治疗组及PCI治疗后1d均有明显下降,差异有统计学意义（P＜0.05）.治疗4周后,强化他汀治疗组血清sol-CXCL16及hs-CRP浓度均较常规治疗组及PCI治疗后1d有明显的下降,差异有统计学意义（P＜0.05）.强化他汀治疗组PCI治疗后4周内主要心血管事件发生率显著低于常规治疗组,差异有统计学意义（P＜0.05）.结论 sol-CXCL16浓度可能与冠状动脉炎症程度相关,并可能对评估急性冠脉综合征患者PCI治疗后短期预后有一定的作用.

Expression patterns of soluble CXCL16 in patients with acute coronary syndrome during the perioperative period of percutaneous coronary intervention

Objectives To investigate the expression patterns of soluble CXCL16 （sol-CXCL16） in patients with acute coronary syndrome （ACS） during the perioperative period of percutaneous coronary intervention （PCI） and to survey its clinical significance.Methods Totally 96 patients with ACS who successfully received PCI were selected and divided into conventional therapy group and intensive statin therapy group.Serum concentrations of sol-CXCL16 and highsensitivity C-reactive protein （hs-CRP） from each group were measured at various time intervals,including day one before and after surgery,two and four weeks after surgery,respectively.Results For all the patients,serum concentrations of both hs-CRP and sol-CXCL16 one day after surgery significantly increased compared to those one day before surgery （P〈0.05）.In addition,an increase on serum concentration of sol-CXCL16 in conventional therapy group one day after PCI was more obvious than that in intensive statin therapy group （P〈0.05）.Serum concentration of solCXCL16 after two weeks in intensive statin therapy group had an apparent decrease by comparing with those in conventional therapy group and one day after surgery in intensive statin therapy group （P〈0.05）.Furthermore,serum concentrations of sol-CXCL16 and hs-CRP after four weeks were significantly lower than those in conventional therapy group and one day after surgery in intensive statin therapy group （P〈0.05）.Major adverse cardiovascular events of four weeks in intensive statin therapy group were significantly lower than those in conventional therapy group （P〈0.05）.Conclusions The study suggests that serum concentration of sol-CXCL16 may correlate with coronary inflammation,which can assess the short-term prognosis of PCI for patients with ACS.