手术联合置管冲洗引流病灶治疗脊柱结核的Meta分析

目的：系统分析手术联合置管冲洗引流病灶治疗脊柱结核的治疗效果。方法：两位研究者独立对数据库包括中国知网、万方数据知识服务平台、维普数据库、PubMed、EMbase、Cochrane Library进行文献检索，收集关于手术联合置管冲洗引流病灶治疗脊柱结核的随机对照试验 (RCT) 与回顾性研究。语种限中、英文。两位研...

Meta-analysis of operation combined with irrigation and drainage of focus lesion in the treatment of spinal tuberculosis

Objective: To systematically analyze the therapeutic effect of operation combined with irrigation and drainage of focus lesion in the treatment of spinal tuberculosis. Methods: Two researchers independently conducted a literature search in China National Knowledge Infrastructure, Wanfang Date, VIP, PubMed, EMbase and Cochrane Library, and collected randomized controlled trials (RCTs) and retrospective studies on the treatment of spinal tuberculosis by surgery combined with catheter irrigation and drainage. The language was limited to Chinese and English. The two researchers independently evaluated the quality of each study, and extracted the preoperative and postoperative data of visual analogue score (VAS), Cobb angle, Erythrocyte sedimentation rate (ESR), C-reactive protein into an electronic baseline table which were analyzed and synthesized by Review Manager 5.4 software to evaluate the effectiveness of this surgical technique in the treatment of spinal tuberculosis. Results: A total of 7 studies with 191 patients were eventually included in the analysis. Meta-analysis results showed that: the mean difference between postoperative VAS scores and preoperative VAS scores was 5.33 (95%CI: 4.11-6.55); The mean difference between Cobb angle after operation and Cobb angle before operation was 14.47° (95%CI: 11.32°-17.61°); The difference between postoperative ESR and preoperative ESR was 40.20 mm/1 h (95%CI: 27.80-52.60); The mean difference between postoperative C-reactive protein and preoperative C-reactive protein was 30.44 mg/L (95%CI: 12.12-48.76). Conclusion: Operation combined with irrigation and drainage had a good therapeutic effect in the treatment of spinal tuberculosis, could effectively reduce the pain level of patients and improve the physical deformity and physical condition of patients, thus to improve the cure rate.