| 人工合成三糖抗原在结核病血清诊断中的初步评价 |
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| 引用本文： | 侯伟,吴勤学,郁华,尹跃平,张津平,蔡秀玲.人工合成三糖抗原在结核病血清诊断中的初步评价[J].中国防痨通讯,1999,21(1):37-38. |
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| 作者姓名： | 侯伟 吴勤学 郁华 尹跃平 张津平 蔡秀玲 |
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| 作者单位： | 中国医学科学院．中国协和医科大学皮肤病研究所； |
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| 摘 要： | 目的评价人工合成三糖抗原在结核病血清诊断的应用前景?方法用人工合成的结核杆菌酚糖酯三糖抗原Tb NT P BSA(naturaltrisaccharide phenylpropionate bovineserumalbumin)作抗原,用ELISA法检测了40例结核患者,52个健康对照的血清标本?结果本方法的特异性?敏感性分别为:检测抗Tb NT P BSAIgG抗体时为94.2%和20.0%;检测抗Tb NT P BSAIgM抗体时为79.6%和45.0%?结论该抗原的特异性?敏感性似不理想,有待进一步改进。
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| 关 键 词： | 结核杆菌酚糖酯三糖抗原 血清诊断 结核 |
| 收稿时间： | 1998-06-09 |
| 修稿时间： | 1998-11-17 |
Evaluation of Tb NT P BSA antigen in the serodiagnosis of tuberculosis |
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| Hou Wei,Wu Qinxue,Yu Hua,et al..Evaluation of Tb NT P BSA antigen in the serodiagnosis of tuberculosis[J].The Journal of The Chinese Antituberculosis Association,1999,21(1):37-38. |
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| Authors: | Hou Wei Wu Qinxue Yu Hua |
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| Institution: | Institute of Dermatology,Chinese Academy of Medical Science and Peking Union Medical College,Nanjing 210042 |
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| Abstract: | Objective To evaluate of Tb NT P BSA antigen in the diagnosis of tuberculosis.Method Sera from 40 tuberculosis cases and 52 healthy controls were assayed by ELISA using Tb NT P BSA(containing the terminal triglycosyl unit of the M.tuberculosis phenolic glycolipid) as antigen.Results The sensitivity and specificity were 94.2%,20.0% for IgG and 79.6%,45.0% for IgM antibody activity respectively.Conclusion This antigen is not sensitive,that will limit its use in the serodiagnosis of tuberculosis. |
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| Keywords: | Tb NT P BSA Serodiagnosis Tuberculosis |
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