直肠异常隐窝病灶对大肠癌和进展型腺瘤的预警作用及其危险因素分析

目的 探讨直肠异常隐窝病灶（ACF）对大肠癌及进展型腺瘤的预警作用,并分析其危险因素.方法 应用独立样本t检验、单向方差分析及卡方检验分析比较直肠ACF的均数及发病率,应用Logistic回归分析直肠ACF与大肠癌及进展型腺瘤的关系,观察是否有预警作用,并筛选对ACF有显著意义的危险因素.结果 5个以上ACF显著增加大肠癌及进展型腺瘤的风险（P＜0.05）;高龄和吸烟为ACF的危险因素,而阿司匹林的应用为其保护因素.结论 5个以上ACF对大肠癌及进展型腺瘤有显著预警作用.在大肠癌的早期预防中,我们应该重视对ACF的形成有意义的影响因素.

Predictive value of rectal aberrant crypt foci for colorectal cancer and progressive adenoma and its risk factors

Objective To investigate the predictive value of rectal aberrant crypt foci(ACF)for colorectal cancer(CRC)and progressive adenomas, and to analyze its risk factors.Methods IndependentSample T test, One-Way ANOVA and Chi-square test were used to analyze the mean number and incidence of rectal ACF.Logistic regression analysis was used to assess the predictive value of rectal ACF for progressive adenomas and CRC, and to identify the independent risk factors of ACF.Results Large number of ACF, i.e.more than 5, was a significant risk factor for CRC and progressive adenomas.Age and smoking were both risk factors of ACF, while aspirin was a protective factor.Conclusion ACF of more than 5 is predictive of CRC and progressive adenomas.For prevention of CRC, great importance must be attached to risk factors of ACF.