少数民族地区吸毒人群艾滋病抗病毒治疗的疗效及影响因素 |
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引用本文: | 陆娟,刘中夫,王凤英,赵德才,豆智慧,张福杰,马烨.少数民族地区吸毒人群艾滋病抗病毒治疗的疗效及影响因素[J].中国艾滋病性病,2013(1):2-5. |
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作者姓名: | 陆娟 刘中夫 王凤英 赵德才 豆智慧 张福杰 马烨 |
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作者单位: | 新疆维吾尔自治区疾病预防控制中心;中国疾病预防控制中心性病艾滋病预防控制中心 |
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摘 要: | 目的 了解少数民族地区吸毒人群艾滋病抗病毒治疗的疗效及其影响因素。方法 对纳入调查的初治吸毒者进行问卷调查和实验室检测,每隔3个月随访1次,观察半年。结果180名初次抗病毒治疗的吸毒者,治疗后6个月余的127人中,123人检测了CD4T淋巴细胞,有12人(占9.8%)免疫学失败;120名已检测病毒载量的病人中,92人病毒载量降至最低检测限以下,病毒学成功率为76.7%。治疗前CD4〈50个/μL者比值比(OR)-0.10,95%可信区间(CI:0.03~O.37]容易发生免疫学失败;半年的服药依从性在95%以上(OR=4.58,95%CI=1.87~12.57)、半年医学随访次数在≥7次(OR=3.23,95%CI=1.16~8.98)者,容易获得病毒学成功。结论吸毒人群的抗病毒治疗疗效低于其他人群,开始抗病毒治疗时间较晚、服药依从性差和参加医学随访次数较少,是造成吸毒人群疗效差的主要原因。
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关 键 词: | 艾滋病 少数民族地区 吸毒人群 抗病毒治疗疗效 影响因素 |
Efficacy evaluation of HAART among IDUs in minority regions and its impact factors |
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Institution: | LU Juan,LIU Zhong-fu,WANG Feng-ying,et al.(Xinjiang Regional Center for Disease Control and Prevention,Urumqi 830002,China) |
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Abstract: | Objective To investigate the efficacy of highly active antiretroviral therapy (HAART) and its impact factors among injection drug users (IDUs) in minority regions. Methods A total of 180 treatment naive IDUs were selected for questionnaire survey and laboratory tests. In a six month study, they were followed-up every 3 months. Results Of the 180 treatment naive IDUs, 127 completed the six month followed-up; 123 patients received CD4 T lymphocyte test, of whom 12 (9.8%) had immunologic failure; 120 patients received plasma viral load (VL) test, of whom 92 (76.7%) had virological suppression, with viral loads under the lowest limit. In the multivariate logistic regression model, those with the baseline CD4 T lymphocyte count less than 50 celts/μL (OR= 0.10,95% CI= 0. 03-0. 37) were prone to have immunologic failure. Those who had the adherence rate over 95% (OR=4.58, 95%CI=1. 87--12. 57) and were interviewed for over 7 times in the half year period (OR=3.23, 95%CI= 1.16-8.98) were prone to be virological success. Conclusion The efficacy of HAART among IDUs is lower than among the other non-drug using people. Being late to start treatment, poor adherence and less follow up are the major im- pact factors related to its efficacy. |
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Keywords: | HIV/AIDS Minority regions IDUs HAART efficacy Impact factors |
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