| 一名HIV/TB双重感染者的HIV分离和鉴定 |
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| 引用本文： | 曾常红,江立敏,颜瑾,林鹏,林恺生,赵茜茜,李晖,徐慧芳.一名HIV/TB双重感染者的HIV分离和鉴定[J].中国艾滋病性病,1999(3). |
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| 作者姓名： | 曾常红 江立敏 颜瑾 林鹏 林恺生 赵茜茜 李晖 徐慧芳 |
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| 作者单位： | 广东省卫生防疫站，广东省卫生防疫站，广东省卫生防疫站，广东省卫生防疫站，广东省卫生防疫站，广东省卫生防疫站，广东省卫生防疫站，广州市卫生防疫站 广州市510300，广州市510300，广州市510300，广州市510300，广州市510300，广州市510300，广州市510300 |
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| 摘 要： | 1996年8月,我们采用改良的正常人PBMCs与病人PBMCs共培养法,从一名HIV/TB双重感染者的PBMCs中分离出1株HIV—1病毒,命名为GD—3.该毒株毒力强,在正常人PBMCs中培养能引起明显的细胞病变,其HIV—1p24抗原滴度超过阈值,但对H_9细胞不敏感.该毒株经基因序列分析为HIV-1E亚型,与广东省其它经性途径感染HIV人群中的HIV-1亚型相同.
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| 关 键 词： | HIV/TB 病毒分离 亚型 |
Isolation and Characterization of HIV from a Patient with HIV/TB Co-infection |
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| ZengChanghong,Jiang Limin,Yan Jin,Xu Huifang,et al..Isolation and Characterization of HIV from a Patient with HIV/TB Co-infection[J].Chinese JOurnal of Aids & STD,1999(3). |
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| Authors: | ZengChanghong Jiang Limin Yan Jin Xu Huifang |
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| Institution: | ZengChanghong,Jiang Limin,Yan Jin,Xu Huifang,et al. Health and Anti -Epidemic Station of Guangdong Province,Guangzhou 510300 |
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| Abstract: | In Augest 1996, a strain of HIV-1 from PBMCs of a HIV/TB co-infected patient by the modified method of co -culturing of PBMCs called DG -3 was isolated. The virus had strong toxicity and could induce apparently cytological pathogenicity in normal PBMCs, its liter of HIV-1 p24 antigen was higher than thresthhold value, but it was slightly reactive to H9 cells. The subtype of the virus was identified by DNA sequence as HIV-1 E similar to HIV-1 subtype which was spreading in the STD population of Guangdong Province. |
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| Keywords: | HIV/TB Virus isolation Subtype |
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