Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide |
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| Authors: | Charlotte Friend William Scher J G Holland and Toru Sato |
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| Institution: | Center for Experimental Cell Biology, Mollie B. Roth Laboratory, The Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029;Division of Cytology, the Sloan-Kettering Institute for Cancer Research, New York, N.Y. 10021 |
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| Abstract: | Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation. |
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