老年人大肠癌中survivin基因的表达及临床意义

目的检测survivin基因在老年人大肠癌、正常大肠黏膜组织上的表达,探讨其临床意义。方法采用免疫组化S-P法对56例老年人大肠癌和33例正常大肠黏膜组织检测survivin基因的表达。结果survivin基因在老年人大肠癌与正常黏膜组织中的表达率分别为48.2%(27例)和12.1%(4例),差异有统计学意(P<0.05),而与组织学分级、Dukes分期、有无淋巴结转移差异无统计学意义。在随访组中,5年存活27例,survivin蛋白阳性表达6例,阳性表达率22.2%;死亡15例中,阳性表达12例(80.0%),差异有统计学意义(P<0.001)。结论survivin基因表达上调可能促进了老年大肠癌的发生,临床上通过检测survivin基因阳性表达率对患者预后可能有临床意义。

Expression of survivin gene in colorectal carcinoma of elderly people and its clinical significance

Objective To investigate the expression of survivin gene in colorectal carcinoma of elderly people and normal colorectal tissue and explore its clinical significance. Methods The expression of survivin gene in 56 cases with colorectal cancer and 33 cases with normal eoloreetal tissue were detected by immunohistochemieal S-P technique.Results The positive rates of survivin in elderly eolorectal carcinoma patients and normal tissue were 48.2% (27/56) and 12.1% (4/33) respectively (P<0.05).In follow-up,the survivin expression were detected in 6 of 27 (22.2%) survival cases after 5 years (P<0.05),in 12 of 15 (80.0%) dead cases (P<0.05).No signifieant difference was found in patients in each histologic grade,each Dukes stage and with or without lymph node metastasis.Conclusions The high expression of survivin may have important prognostic implications in elderly patients with colorectal carcinoma.