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2型糖尿病血清淀粉样蛋白A水平与颈总动脉内中膜厚度相关
引用本文:杨郁,杜建玲,张秀娟,白然,巴颖,邢倩,孙丽鹏,孙国华,李昌臣. 2型糖尿病血清淀粉样蛋白A水平与颈总动脉内中膜厚度相关[J]. 中华内分泌代谢杂志, 2008, 24(2)
作者姓名:杨郁  杜建玲  张秀娟  白然  巴颖  邢倩  孙丽鹏  孙国华  李昌臣
作者单位:1. 大连医科大学附属第一医院内分泌科
2. 大连医科大学附属第一医院超声科
3. 大连医科大学附属第一医院检验科
摘    要:169 例短病程2型糖尿病患者,根据大动脉内中膜厚度(IMT)分为动脉粥样硬化(AS)组和非AS组,测定血清淀粉样蛋白A(SAA)水平,结果显示2型糖尿病组SAA水平较对照组高,AS组高于非AS组,并与年龄、体重指数、腰臀比及颈总动脉IMT呈正相关;年龄、C反应蛋白及SAA是影响颈总动脉IMT的相关因素.

关 键 词:血清淀粉样蛋白A  糖尿病  2型  动脉内中膜厚度

Association between serum amyloid A and intima-media thickness of common carotid artery in patients with type 2 diabetes
YANG Yu,DU Jian-ling,ZHANG Xiu-juan,BAI Ran,BA Ying,XING Qian,SUN Li-peng,SUN Guo-hua,LI Chang-chen. Association between serum amyloid A and intima-media thickness of common carotid artery in patients with type 2 diabetes[J]. Chinese Journal of Endocrinology and Metabolism, 2008, 24(2)
Authors:YANG Yu  DU Jian-ling  ZHANG Xiu-juan  BAI Ran  BA Ying  XING Qian  SUN Li-peng  SUN Guo-hua  LI Chang-chen
Abstract:A total of 169 patients with short-duration type 2 diabetic mellitus (DM) were divided into atherosclerosis (AS) group and non-AS group according to the intima-media thickness (IMT) of three conducting arteries.The level of serum amyloid A (SAA) was assayed by ELISA.The results showed that SAA level of type 2 DM patients increased significantly, patients in AS group showed higher SAA level than that in non-AS group, and SAA level was positively correlated with age, body mass index, waist hip ratio and IMT of common carotid artery.Age, C-reactive protein and SAA level are the major risk factors for IMT of common carotid artery.
Keywords:Serum amyloid A  Diabetes mellitus  type 2  Intima-media thickness
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