| 抑制NF-κB活性下调高糖培养的大鼠肾小球系膜细胞血管紧张素原表达水平 |
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| 引用本文： | 李津,郭颖,黄滨,丁鹤林,傅祖植.抑制NF-κB活性下调高糖培养的大鼠肾小球系膜细胞血管紧张素原表达水平[J].中华内分泌代谢杂志,2010,26(5). |
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| 作者姓名： | 李津 郭颖 黄滨 丁鹤林 傅祖植 |
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| 作者单位： | 1. 福建省厦门市第一医院干部病房
2. 中山大学附属第二医院内分泌科,广州,510120 |
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| 摘 要： | 在体外原代培养的SD大鼠肾小球系膜细胞中,观察高糖培养条件下血管紧张素原(AGT)表达和血管紧张素Ⅱ(AngⅡ)水平变化,以及吡咯烷二硫代氨基甲酸酯(PDTC)的干预作用.结果 显示高糖上调ACT mRNA(0.29±0.07对0.20±0.05,P<0.05)和蛋白(0.66±0.23对0.37±0.15,P<0.05)表达以及AngⅡ分泌(9.85+2.08对7.50±1.51)ps/ml,P<0.05]水平,PDTC通过抑制NF-κB活性下调其水平.
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| 关 键 词： | 肾小球系膜细胞 NF-κB 血管紧张素原 血管紧张素Ⅱ |
Inhibiting NF-κB activity down-regulates angiotensinogen expression level in cultured rat mesangial cells |
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| LI Jin,GUO Ying,HUANG Bin,DING He-lin,FU Zu-zhi.Inhibiting NF-κB activity down-regulates angiotensinogen expression level in cultured rat mesangial cells[J].Chinese Journal of Endocrinology and Metabolism,2010,26(5). |
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| Authors: | LI Jin GUO Ying HUANG Bin DING He-lin FU Zu-zhi |
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| Abstract: | The angiotensinogen(AGT) expression and angiotensin Ⅱ (AngⅡ ) secretion levels in cultured SD rat mesangial cells were determined. High glucose up-regulated AGT mRNA(0. 29±0.07 vs 0. 20±0. 05,P< 0.05)and protein(0.66±0.23 vs 0.37±0. 15,P<0.05) expression and Ang Ⅱ secretion (9.85±2.08 vs 7.50± 1. 51) pg/ml,P<0. 05]levels, which were down-regulated by pyrrolidine dithiocarbamate( PDTC) treatment via inhibiting NF-κB activity. |
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| Keywords: | Mesangial cells NF-kB Angiotensinogen Angiotensin Ⅱ |
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